血浆脑利钠肽水平与急性期缺血性脑卒中预后的相关研究

Studies of plasma brain natriuretic peptide levels in prognosis of patients with acute ischemic stroke

目的对急性期缺血性脑卒中患者的血浆脑利钠肽(BNP)水平进行检测,探讨其在患者预后恢复中的预测价值。方法对2011年1月至2013年6月间在高州市人民医院治疗的102例急性期缺血性的脑卒中患者病历进行回顾性分析。根据治疗和随访结果,将患者分为好转组和死亡组,对患者的BNP水平进行检测,并将50名健康者进行比较。结果治疗前急性期缺血性脑卒中患者BNP水平为(732.72±631.38)pg/ml,高于健康者的(94.59±45.03)pg/ml,差异有统计学意义(t=22.168,P<0.001)。治疗1周后,急性期缺血性脑卒中患者BNP水平降至(493.29±318.53)pg/ml,与治疗前比较差异有统计学意义(t=8.725,P=0.007)。死亡组患者的BNP水平为(1 496.46±712.84)pg/ml,高于好转组的(573.31±359.12)pg/ml,差异有统计学意义(P<0.05)。结论 BNP水平随患者病情的严重会升高,可作为预后的快速预测指标因子。

Objective To detect plasma brain natriuretic peptide （BNP） levels of patients with acute ischemic stroke, and explore its predictive value in the prognosis of patients recovery. Methods 102 patients with acute ischemic stroke in our hospital from January 2011 to June 2013 were retrospectively analyzed. Based on treatment and follow-up results, patients were divided into improved group and death group. The BNP levels were detected and compared with that of control group （50 healthy）. Results BNP levels of patients at admission was （732.72±631.38）pg/ml, which was higher than that of healthy people （94.59±45.03）pg/ml, the difference was statistically significant （P〈0.05） ; After 1 week＇s treatment, BNP levels of patients reduced to （493.29±318.53）pg/ml from （732.72±631.38）pg/ml of admission, the difference between before and after treatment was statistically significant （P〈0.05） ; BNP levels of death group was （1 496.46±712.84）pg/ml, which was higher than that of improved group （573.31±359.12）pg/ml, the difference was statistically significant （P〈0.05）. Conclusion BNP levels of patients would increase with severity of the disease, which can be used as a quick predictor factor for prognosis.