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过氧化物酶体增殖体活化受体-γ对白细胞介素-13诱导杯状细胞增生的影响

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摘要 气道黏液过量分泌导致气道阻塞、细菌定植，这是许多慢性气道炎症性疾病共同的病理特征，与支气管哮喘、支气管扩张症和慢性阻塞性肺疾病等慢性气道炎症性疾病的发生、发展及转归密切相关，并已成为影响其发病率和病死率的独立危险因素和临床治疗的突出问题，但目前尚无治疗气道黏液高分泌的有效药物。
作者 凤婧 汤小菊 陈一帆 吴庆波 罗凤鸣
机构地区 四川大学华西医院呼吸内科 四川大学再生医学中心
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2014年第6期450-451,共2页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 国家自然科学基金（30871118,30971325,81270129）
关键词 白细胞介素-13 过氧化物酶体 细胞增生 活化受体 慢性气道炎症性疾病 气道黏液高分泌 增殖体 慢性阻塞性肺疾病
分类号 R56 [医药卫生—呼吸系统]
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参考文献7

  • 1刘剑波,张珍祥,徐永健,邢丽华,张惠兰.白细胞介素13对小鼠支气管哮喘模型肺组织钙激活的氯通道gob-5和黏蛋白基因MUC5AC表达的作用[J].中华结核和呼吸杂志,2004,27(12):837-840. 被引量：9
  • 2Zhen G,Park SW,Nguyenvu LT,et al.IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production[J] .Am J Respir Cell Mol Biol,2007,36:244-253.
  • 3Wan H,Kaestner KH,Ang SL,et al.Foxa2 regulates alveolarization and goblet cell hyperplasia[J] .Development,2004,131:953-964.
  • 4欧雪梅,冯玉麟,文富强,王可,徐丹,张建勇.大环内酯类抗生素对气道黏液高分泌过程的调控作用及其机制研究[J].中国呼吸与危重监护杂志,2006,5(2):140-145. 被引量：8
  • 5Tang X,Liu XJ,Tian C,et al.Foxa2 regulates leukotrienes to inhibit Th2-mediated pulmonary inflammation[J] .Am J Respir Cell Mol Biol,2013,49:960-970.
  • 6Lee SY,Kang E J,Hur GY,et al.Peroxisome proliferatoractivated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells[J] .Am J Physiol Lung Cell Mol Physiol,2006,291:L84-L90.
  • 7Allahverdian S,Harada N,Singhera GK,et al.Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF[J] .Am J Respir Cell Mol Biol,2008,38:153-160.

二级参考文献18

  • 1Bousquet J, Jeffery PK, Busse WW, et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med, 2000,161:1720-1745.
  • 2Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science, 1998, 282: 2258-2261.
  • 3Fuller CM, Benos DJ. Ca2+-Activated Cl- Channels: a newly emerging anion transport family. News Physiol Sci, 2000, 15:165-171.
  • 4Poynter ME, Irvin CG, Janssen-Heininger YM. Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol, 2002,160:1325-1334.
  • 5Gruber AD, Elble RC, Ji HL, et al. Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. Genomics, 1998, 54:200-214.
  • 6Nakanishi A, Morita S, Iwashita H, et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA, 2001, 98: 5175-5180.
  • 7Hoshino M, Morita S, Iwashita H, et al. Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway. Am J Respir Crit Care Med, 2002, 165:1132-1136.
  • 8Zhou Y, Dong Q, Louahed J, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol, 2001, 25: 486-491.
  • 9Danahay H, Atherton H, Jones G, et al. Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol, 2002, 282:L226-L236.
  • 10Vestbo J, Prescott E, Lange P. Association of chronic mdcus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group.Am J Respir Crit Care Med, 1996, 153: 1530-1535.

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中华结核和呼吸杂志
2014年 第6期

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