PTEN、cyclinE在绝经前妇女子宫内膜息肉中表达情况及相关性分析

Relationship and Expression of PTEN,CyclinE in Premenopausal Women with Endometrial Polyp

目的：探讨PTEN、cyclinE在绝经前妇女子宫内膜息肉中表达情况并分析其相关性。方法：入选2009年12月-2012年7月在我就诊的子宫内膜息肉患者72例作为观察组,并入选同期在我院进行体检的绝经前妇女73例作为对照组,比较两组人群子宫内膜PTEN、cyclinE表达情况,并分析二者之间的相关性。结果：对照组患者PTEN、cyclinE阳性表达率分别为50.7%、19.2%与观察组患者26.4%、65.3%相比,差异均具有显著的统计学意义（R＜0.05）。分析显示,子宫内膜息肉患者中PTEN、cyclinE表达存在明显的负相关,r=-0.423（R＜0.05）。结论：绝经前妇女子宫内膜息肉患者中cyclinE表达明显增加,PTEN表达显著减少,二者存在显著的负相关。

Objective：To investigate the expression of PTEN, cyclinE in premenopausal women with endometrial polyp and analyze their relationship. Methods：72 premenopausal women with endometrial polyp from December 2009 to July 2012 in our hospital were enrolled as observation group;73 healthy premenopausal women were also enrolled as control group, the expression of PTEN、cyclinE was compared in two groups, and the relationship was analyzed between PTEN and cyclinE. Results：The positive expressions of PTEN、cyclinE in control group were 50.7%,19.2%and 26.4%、65.3%in observation group, all R〈0.05;there was significant negative correlation between PTEN and cyclinE, r=-0.423 （R〈0.05）. Conclusion：The expression of cyclinE in premenopausal women with endometrial polyp significantly increased, and PTEN significantly reduced;there was significant negative correlation between them.