急性冠脉综合征患者颈动脉斑块与血清IL-6、sIL-6R的变化关系研究

Study of the Relationship of IL-6,sIL-6R and Carotid Artery Plaque with Acute Coronary Syndrome

目的:急性冠脉综合征患者血清白介素-6(IL-6)、可溶性白介素-6受体(sIL-6R)水平及颈动脉斑块性质的变化并探讨其临床意义。方法:随机选择ACS患者50例,对照组15例,采用ELISA法测定血清IL-6、sIL-6R值进行比较;同时采用高分辨率B型超声进行双侧颈动脉斑块检测,并根据超声回声特点分成稳定和不稳定斑块。结果:ACS组血清IL-6值和不稳定斑块数明显高于对照组,而sIL-6R则低于对照组,两组间的差异均具有统计学意义(P<0.05)。结论:ACS的发生主要与动脉粥样硬化斑块的稳定性有关,而斑块的稳定性与IL-6水平负相关,与sIL-6R正相关。

Objective：To detect the changes and clinical significance of serum IL-6、sIL-6R and the stability of carotid artery atherosclerotic plaque in patients with acute coronary syndrome（ACS）.Methods：50 cases of ACS and 44case of control were selected, serum levels of IL-6, sIL-6R were measured by ELISA, at the same time bilateral carotid artery were investigated with high resolution B mode ultrasound as well as the carotid plaques were divided into stable and unstable. Results：Patients with ACS had higher serum IL-6 levels and much more quantity of unstable plaques than controls,but the levels of serum sIL-6R were contrary to IL-6,the difference was statistically significant （P〈0.05）. Conclusion：ACS is correlated with stability of artery atherosclerotic plaque, the stability of artery atherosclerotic plaque was negatively correlation with the levels of IL-6 and positively correlated with sIL-6R.