150例疱疹性咽峡炎临床资料总结及分析

Summary and Analysis of the Clinical Data of 150 Cases of Herpangina

目的：总结分析150例疱疹性咽峡炎的临床症状体征以及治疗转归。方法：收集2011年3月至2013年4月我院住院疱疹性咽峡炎患儿150例的临床资料并进行回顾性总结及分析。结果：150例中有29例发展成为手足口病,1例为重症；全部进行心肌酶检查,异常率85.33%（128/150）,其中CKMB异常者67例占52.34%；经过营养心肌治疗7-10天后复查心肌酶24例正常,继续治疗至20天后再次复查32例恢复正常。全部进行肝功能检测,26例转氨酶升高,占32.0%（68/150）；部分心电图检查异常率占28.21%（22/78）异常,主要表现在心率改变。89例检查胸片23例诊断为急性支气管炎或者支气管肺炎。治疗后除9例好转出院外,其余均治愈出院。转手足口病区的29例患儿经治疗均痊愈出院。结论：疱疹性咽峡炎部分可发展至手足口病,需临床多观察以便早期隔离治疗,以疱疹性咽峡炎为早期表现的手足口病预后良好。疱疹性咽峡炎易引起多脏器功能损伤,尤以心肌损害为多发,及早发现及早治疗能取得满意疗效,应引起高度重视。

Objective：To summarize and analyze the clinical features and prognosis of 150 cases of herpangina. Methods：The clinical data of 150 cases of herpangina children who were admitted into our hospital from Mar. 2011 to Mar. 2013 were retrospectively summarized and analyzed. Results：Among 150 children, 29 cases were hand-foot-mouth disease（HFM）（1 severe case）. The abnormal rate of myocardial enzyme （ME） inspection was 85.33%（128/150）, among them, CKMB was 52.34%（67 cases）. The ME of 24 cases recovered after 7-10 days of myocardial nutrient, 32 cases recovered after continued treatment to 20 days. For the aspect of liver function inspection, the transaminase of 26 cases were increased （32%, 68/150）. Part of ECG abnormal rate was 28.21%（22/78）, mainly displays in heart rate change. 23 cases were diagnosed with acute bronchitis or bronchitis or bronchitis. All children were discharged from hospital （9 cases were improved and the rest was recovered）, meanwhile, the children who were transferred to HFM ward were also discharged. Conclusion：Herpangina can develop into HFM, so more observation and early isolation should be applied. The herpangina early manifested HFM has a good prognosis, while herpangina can induce multiple organ function injury, especially with myocardial damage, early detection and treatment could improve the clinical effect and high attention should be paid.