甘露聚糖肽治疗脑出血并发医院感染的疗效观察

Observation of the Efficacy of Mannatide in Treatment with Cerebral Hemorrhage Complicated with Nosocomial Infection

目的：探讨甘露聚糖肽注射液治疗脑出血患者并发医院感染的临床疗效。方法：2010年4月-2013年9月期间脑出血患者96例,随机分为实验组和对照组,各48例,实验组患者在常规药物治疗基础上加用甘露聚糖肽注射液治疗,静脉点滴,10mg/次,1次/天,连用2周；对照组患者根据病情选用常规方法对症治疗,用法用量与治疗组相同。观察患者治疗后总有效率和合并感染发生率,以及NIHSS评分、改良Rankin量表评分（mRS评分）和血清IgG、IgA、IgM和补体C3水平。结果：（1）治疗前NIHSS评分、mRS评分相比差异无统计学意义（P〉0.05）。治疗后,实验组NIHSS评分、mRS评分显著低于对照组,两组患者之间相比差异有统计学意义（P〈0.05）。（2）实验组患者治疗效果显著优于对照组患者,差异有统计学意义（P〈0.05）。（3）治疗后患者IgG、IgA、IgM和补体C3水平较治疗前明显升高（P〈0.05）,实验组升高幅度明显大于对照组（P〈0.05）,同时患者在救治过程中并发感染发生率也显著下降,与对照组比较差异具有统计学意义。结论：甘露聚糖肽注射液能降低脑出血合并感染的发生率,并能改善预后,有助于患者康复。

Objective：To observe the clinical efficacy of Mannatide injection in treatment of cerebral hemorrhage patients with nosocomial infection.Methods：96 patients with cerebral hemorrhage during hospital from April 2010 to September 2013 were randomly divided into experimental group and control group.48 cases in the experimental group were given traditional drug therapy plus Mannatide injection by intravenous,10mg/time,1time/day for two weeks.The control group were given conventional therapy according to the symptomatic,the dosage and administration were the same as the experimental group.The total effective rate and the incidence of infection were observed after treatment,NIHSS score,mRS,serum IgG, IgA,IgM and complement C3 levels were also observed.Results：（1）There was no statistically significant difference between NIHSS and mRS scores （P〉0.05）.The NIHSS and mRS scores of treatment group were significantly lower than that of the control group after treatment with significant difference （P〈0.05）. （2）The efficacy of experimental group were significant superior than the control group with the statistical significance （P〈0.05）. （3）IgG, IgA, IgM and complement C3 level was significantly higher after treatment （P〈0.05）,the experimental group increased more significantly than the control group.The incidence of complicated infection in experimental patients during therapy was also decreased significantly compared with the control group.Conclusion：Mannatide injection can reduce the incidence of cerebral hemorrhage complicated with infection,and can improve the prognosis and help the rehabilitation of patients.