游离脂肪酸相关因素分析

Related Factors Analysis of Free Fatty Acids

目的:探讨血清游离脂肪酸(FFA)与载脂蛋白A(ApoA)、载脂蛋白B(ApoB)、脂蛋白a(Lpa)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的关系以及血清游离脂肪酸与冠心病的关系。方法:选择2011年5月在我院体检的患者随机抽取200例分析FFA和血脂水平;选择在我院心脏科治疗的50例冠心病患者为冠心病组,同期50例体检健康者为对照组,比较两组FFA水平对结果进行分析。结果:FFA与TG(r=-0.22,P>0.05)、Chol(r=0.11,P>0.05)、HDL-C(r=0.18,P>0.05)、LDLC(r=0.29,P>0.05)、ApoA(r=0.39,P>0.05)、ApoB(r=0.12,P>0.05)、Lp(a)(r=0.09,P>0.05),冠心病组FFA为(0.65±0.31)mmol/L,健康对照组FFA为(0.52±0.30)mmol/L。两组比较差异有统计学意义(t=3.01,P<0.01)。结论:血清游离脂肪酸可能是冠心病的危险因子,值得进一步研究。

Objective： To investigate serum free fatty acid （FFA） and apolipoprotein A （ApoA）, apolipoprotein B （ApoB）, lipoprotein a （Lpa）, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） as well as the relationship between serum free fatty acids and coronary heart disease. Methods：Select the May 2011 examination of the patients in our hospital were randomly selected 200 cases analyzed FFA and lipid levels;selected 50 cases of coronary heart disease in patients treated in our hospital cardiology coronary heart disease group, compared with 50 cases of healthy people as a control group to compare FFA levels for both groups were analyzed. Results： FFA and TG （r=-0.22, P〉0.05）, Chol （r=0.11, P〉0.05）, HDL-C （r=0.18, P〉0.05）, LDL-C （r=0.29, P〉0.05） , ApoA （r=0.39, P〉0.05）, ApoB （r=0.12, P〉0.05）, Lp （a） （r=0.09, P〉0.05）, FFA CHD group was （0.65±0.31）mmol/L healthy control group FFA was （0.52±0.30）mmol/L. The difference was statistically significant （t=3.01, P〈0.01）. Conclusion：The serum free fatty acid may be a risk factor for coronary heart disease, deserves further study.