快速康复外科对胃癌手术效果及炎症介质释放的影响

Effect of Fast Track Surgery on the Effect of Gastric Cancer Operation and Release of Inflammatory Mediators

目的:探讨加速康复外科理念(FTS)应用胃癌患者对手术效果及炎症介质释放的影响。方法:选择120例胃癌患者作为研究对象,随机分为观察组对照组各60例,对照组实施胃癌围手术前常规处理,观察组实施FTS。结果:观察组手术时间(97.34±12.23)min、术中出血量(228.76±65.39)ml、进食时间(7.11±0.67)d、术后并发症发生率11.67%、术后住院时间(10.72±2.34)d少于对照组的(126.43±16.34)min、(475.32±80.25)ml、(9.45±1.12)d、30.00%、(14.20±2.78)d(P<0.05);观察组术后血清CRP(7.56±2.03)mg/L、IL-6(67.23±15.45)ng/L、TNF-α(0.35±0.12)ng/L等促炎症性细胞因子,免疫调节因子IL-2(3.42±1.03)ng/L低于对照组(13.34±2.13)mg/L、(98.42±22.38)ng/L、(0.58±0.11)ng/L、IL-2(5.12±1.38)ng/L(P<0.05);抗炎症因子IL-10(13.45±3.45)ng/L高于对照组(8.37±2.47)ng/L(P<0.05)。结论:FTS理念用于胃癌围手术期可以减少促炎症细胞因子的释放且增加抗炎症细胞因子的释放,从而降低机体因手术创伤发生的炎症反应,促进患者快速康复。

Objective：To explore the operation effect and the release of inflammatory mediators of the fast track surgery （FTS） in application of patients with gastric cancer.Methods：120 cases of gastric cancer patients as research object, randomly divided into observation group and control group each 60 cases, the control group of gastric cancer during operation of conventional treatment, the observation group to implement FTS.Results：The observation group operation time （97.34 ± 12.23） min, amount of bleeding during the operation （228.76 ± 65.39） ml, eating time （7.11±0.67）D, the incidence of postoperative complications was 11.67%, postoperative hospitalization time （10.72 ± 2.34） d less than that of the control group （126.43±16.34） min, （475.32± 80.25） ml, （9.45 ± 1.12） d, 30%, （14.20 ± 2.78） d （P〈0.05）;the serum CRP level of the patients in the observation group（7.56±2.03）mg/L、IL-6（67.23±15.45） ng/L、TNF-α（0.35±0.12）ng/L promote inflammatory cytokines, immune regulation factor IL-2（3.42±1.03）ng/L lower than that of the control group （13.34±2.13）mg/L、（98.42±22.38）ng/L、（0.58±0.11）ng/L、IL-2（5.12±1.38）ng/L（P〈0.05） anti-inflammatory factor IL-10（13.45±3.45）ng/L higher than that of the control group（8.37±2.47）ng/L （P〈0.05）.Conclusion：The concept of FTS for gastric cancer during operation can reduce proinflammatory cytokine release and increase the anti-inflammatory cytokine release, thereby reducing the body due to inflammatory response operation trauma, promote the rapid rehabilitation of patients.