甘露聚糖肽联合介入治疗对晚期胰腺癌的临床疗效分析

The Clinical Efficacy Analysis of Mannatide Combined with Interventional Therapy in the Treatment of Patients with Advanced Pancreatic Cancer

目的：探讨甘露聚糖肽联合介入化疗治疗晚期胰腺癌的临床效果。方法：选用2008年05月-2012年03月我院介入科和放疗科共收治晚期胰腺癌患者74例,随机分为观察组和对照组,各37例,均采用改良Seldinger法行股动脉穿刺,通过动脉置管,血管造影,确定靶血管,行动脉灌注化疗。同时观察组加用甘露聚糖肽注射液,静脉点滴,10mg/天。治疗周期为4周。结果：观察组患者治疗后疼痛缓解总有效率为83.78%,与对照组的62.15%比较具有统计学差异（P=0.036）。观察组治疗后生活质量（KPS评分）改善率为91.89%,与对照组的72.97%比较具有统计学差异（P=0.033）。观察组1年生存率、2年生存率均显著高于对照组（P值分别为0.038,0.036）。结论：应用甘露聚糖肽联合动脉灌注化疗治疗胰腺癌,能有效提高化疗的临床疗效,改善患者生活质量,延长生存时间。

Objective：To observe the clinical efficacy of mannatide combined with interventional therapy in the treatment of patients with advanced pancreatic cancer.Methods：74 patients with advanced pancreatic cancer admitted to interventional radiology and radiotherapy department in our hospital from May 2008 to March 2012 were randomly divided into treatment group and control group. Both groups were given modified Seldinger method for femoral artery puncture. By artery catheterization, angiography, the target vessels were determined and arterial infusion chemotherapy were given. The treatment group were given additional mannatide injection by intravenous, 10mg/day for 4 weeks.Results：The total effective rate of pain relief in the treatment group after treatment was 83.78%, with statistically difference from 62.15%in the control group （P=0.036）. The improvement rate of quality of life （KPS score） in the observation group was 91.89% after treatment, with statistically difference from 72.97% in the control group （P=0.033）.The 1-year and 2-year survival rates of the treatment group were significantly higher than that of the control group （P=0.038,0.036）.Conclusion：The application of Mannatide combined with arterial infusion chemotherapy for pancreatic cancer can improve the clinical efficacy of chemotherapy effectively, improve quality of life and prolong survival time.