TUVP联合间歇性和持续性雄激素去势对改善晚期前列腺癌患者生活质量和总生存率的影响

The Impact of TUVP Combined with Intermittent or Continuous Androgen Blockade on the Quality of Life and Overall Survival for Patients with Advanced Prostate Cancer

目的:探讨TUVP联合间歇性和持续性雄激素去势对改善晚期前列腺癌患者生活质量和总生存率的影响。方法:随机抽取我院136例晚期前列腺癌患者,将其分为两组,对照组69例,采用TUVP联合持续性雄激素去势治疗,观察组67例,采用TUVP联合间歇性雄激素去势治疗;比较两组治疗3个月后的国际前列腺症状评分、生活质量评分及随访一年后总生存率之间的差异。结果:治疗3个月后,观察组患者在国际前列腺评分、生活质量评分及随访一年后的总生存率分别为1.85±0.48,1.85±0.48,89.55,明显优于对照组,差异有统计学意义(P<0.05)。结论:对晚期前列腺癌患者来说,TUVP联合间歇性雄激素去势治疗是安全有效的治疗方法,能明显改善患者的临床症状,提高生活质量,提高癌症患者的总生存率。

Objective：To the impact of TUVP combined intermittent or continuous androgen blockade on the quality of life and overall survival for patients with advanced prostate cancer.Methods：A total of 136 advanced prostate cancer patients were selected randomly.They were divided into observation group （n=67） and control group（n=69） . The observation groups treated with TUVP conbined IAB. The control groups treated with TUVP conbined CAB .Compared two groups Treatment of Cancer Quality of Life,international prostate symptom score,a year of overall survival.Results：Three months after treatment, patients treated with TUVP conbined IAB presented with decreased Cancer Quality of Life、international prostate symptom score compared to control group before treatment（P〈0.05）. A year after treatment, patients treated with TUVP conbined IAB overall survival were improved compared to control group before treatment （P〈0.05）.Conclusion：TUVP conbined IAB can effectively improve the quality of life for patients with advanced prostate cancer. Improve patient＇s patients.