低分子肝素治疗频发短暂性脑缺血发作61例疗效观察

Effect of low molecular weight heparin on 61 cases with frequent transient ischemic attack

目的探讨低分子肝素钙治疗频发短暂性脑缺血发作(TIA)的临床疗效和安全性。方法 120例频发TIA患者随机分为观察组(61例)和对照组(59例)。两组均常规治疗,观察组加用低分子肝素皮下注射,共10d。观察两组患者总有效率、治疗前后出凝血指标和复发率变化。结果观察组总有效率(93.44%)明显高于对照组(67.80%),差异有统计学意义(P<0.05),观察组复发率(3.28%)明显低于对照组(13.56%),差异有统计学意义(P<0.05),两组治疗前后出凝血指标比较,差异无统计学意义(P>0.05)。结论低分子肝素治疗频发短暂性脑缺血发作近远期疗效显著,安全性高,明显降低复发率和改善预后,值得临床推广应用。

Objective To observe the clinical efficacy and safety of low molecular weight heparin（LMWH）calcium in treatment of patients with frequent transient ischemic attack（TIA）.Methods The 120 TIA patients were randomly allocated to observation group（61 cases）and control group（59 cases）.The control group received conventional therapy and those in the observation group were based on the conventional therapy,injected with LMWH for 10 days.The results of the total efficacy,coagulation index and the recurrence rates were analyzed.Results The recurrence rate of the observation group showed significant differences compared to the control group（P〈0.05）,the total effective rate of the observation group was 93.44%significant than the control group（P〈0.05）.No significant difference was noticed in coagulation indicators between the two groups（P〈0.05）.Conclusion Low molecular weight heparin is markedly effective in treatment of frequent transient ischemic attack with high safety,low recurrent rate and good prognosis suitable for clinical application.