摘要
OBJECTIVE: To investigate the antidepressant effects of the Radix et Caulis Acanthopanacis Santicosi extracts in response to the tail suspension test(TST)and forced swim test (FST) in rats.METHODS:Male Wistar rats (9-week-old) wereorally administered the Radix et Caulis Acanthopanacis Santicosi extracts(30, 100 and 300 mg/kg) daily for 14 consecutive days. Serum corticosterone level was measured by using commercially available kit.The c-fos immunoreactivity was analyzed using immunohistochemistry methods.RESULTS:The effect of Radix et Caulis Acanthopanacis Santicosi extracts on the immobility time was significantly decreased at high-dose(300 mg/kg)treated group in the TST and FST(47.7%and69.6%,P<0.05), and decreased the hypothalamic-pituitary-adrenal(HPA) axis response to the stress,as in-dicated by an attenuated corticosterone response anddecreasedc-fosimmunoreactivity in the hippocampal and hypothalamic paraventricular nucleus region.CONCLUSION:Radix et Caulis Acanthopanacis Santicosi extracts have beneficial effects on depression behaviors and restore both altered c-fos expression and HPA activity.Thus, Radix et Caulis Acanthopanacis Santicosi extracts may be a novel agent for the treatmentof stress-related disorders.
OBJECTIVE： To investigate the antidepressant ef- fects of the Radix et Caulis Acanthopanacis Santicosi- extracts in response to the tail suspension test （TST） and forced swim test （FST） in rats. METHODS： Male Wistar rats （9-week-old） were oral- ly administered the Radix et Caulis Acanthopanacis Santicosi extracts （30, 100 and 300 mg/kg） daily for 14 consecutive days. Serum corticosterone level was measured by using commercially available kit. The c-fos immunoreactivity was analyzed using im- munohistochemistry methods. RESULTS： The effect of Radix et Caulis Acanthopana- cis Santicosi extracts on the immobility time was significantly decreased at high-dose （300 mg/kg） treated group in the TST and FST （47.7% and 69.6%, P〈0.05）, and decreased the hypothalamic-pitu- itary-adrenal （HPA） axis response to the stress, as in-dicated by an attenuated corticosterone response and decreased c-fos immunoreactivity in the hippo- campal and hypothalamic paraventricular nucleus region. CONCLUSION： Radix et Caulis Acanthopanacis Santi- cosi extracts have beneficial effects on depression behaviors and restore both altered c-fos expression and HPA activity. Thus, Radix et Caulis Acanthopana- cis Santicosi extracts may be a novel agent for the treatment of stress-related disorders.
基金
Supported by Research and development project for mental health food from the Korea Food Research Institute
