抗菌药物致甲状腺疾病手术患者不良事件的临床评价

Clinical Evaluation on the Adverse Events Induced by Antibacterial Drugs in Patients Undergoing Thyroid Surgery

目的:探讨甲状腺疾病手术患者围手术期抗菌药物的不良反应与合理应用。方法:采用随机数字表法,选取沈阳市某三级甲等医院的甲状腺疾病手术住院患者400例,提取病历中抗菌药物的应用信息,并设计《抗菌药物应用不良事件调查表》,对包括围手术期患者基本情况、抗菌药物使用情况、不良事件发生情况进行统计、分析。结果:抗菌药物不良事件发生率为26.16%,以头孢菌素类药物(29.94%)为主,临床表现以消化道系统不良事件比例最高(30.26%)。结论:甲状腺疾病围手术期抗菌药物使用的不良事件问题严重,主要由头孢菌素类抗菌药物引起。因此需加强对头孢菌素类抗菌药物的监管,关注患者用药后的变化,促进抗菌药物的合理使用。

OBJECTIVE：To investigate the adverse drug reactions and rational use of antibacterial drugs in patients undergoing thyroid surgery during perioperative period.METHODS：Using random number table,400 inpatients undergoing thyroid surgery in a ＂Three-A＂ level hospital in Shenyang were included for data collection regarding the use of antibacterial drugs; meanwhile,＂questionnaire on the adverse events of antibacterial drugs＂ was designed for statistical analysis regarding the basic information of the patients,the use of antibacterial drugs and the incidence of adverse events.RESULTS：The incidence rate of adverse events was 26.16%,which were mostly caused by cephalosporins （29.94%） and occurred more often in digestive system （30.26%）.CONCLUSIONS：The adverse reactions of the antibacterial drugs in patients undergoing thyroid surgery during perioperative period are serious,which are mainly induced by cephalosporin antibiotics.Hence it is important to strengthen the supervision during using cephalosporin antibiotics and pay close attention to changes in the patient after administration of drugs in an effort to promote the rational use of antibacterial drugs.