血清半胱氨酸蛋白酶抑制剂C和尿微量白蛋白检测窒息新生儿的临床意义

Clinical application of serum Cyst- C and urinary microalbumin in early kidney damage in asphyxiated neonates

目的 探讨血清半胱氨酸蛋白酶抑制剂C（Cyst-C）和尿微量白蛋白（mA1b）在窒息新生儿早期肾损害中的临床意义.方法 选择2012-01～2013-12东莞市横沥医院NICU住院的窒息足月新生儿60例为研究组.随机选择同期本院产科出生的无窒息及无产伤的正常足月新生儿30例为对照组.分别检测两组患儿血清肌酐（Scr）、血清Cyst-C和尿mA1b,同时对研究组做尿常规检测.结果 研究组患儿血清Cyst-C为2.24±0.81 mg/L,高于对照组的0.85±0.20 mg/L,尿mA1b为20.04±10.32mg/L,高于对照组的2.30±1.38mg/L.两者比较差异有非常显著性意义（P＜0.01）;研究组患儿的尿常规异常率为35.0％ （21/60）,分别与尿mA1b异常率61.7％（37/60）、血清Cyst-C异常率71.7％ （43/60）比较,差异有非常显著性意义（P＜0.01）.结论 血清Cyst-C联合尿mA1b检测是诊断窒息新生儿早期肾损害的灵敏指标,可作为临床早期诊断的可靠依据.

Objective To investigate the clinical significance of serum Cyst - C and urinary microalbumin in early renal impairment in asphyxiated neonates. Methods Sixty newborn infant with asphyxia in our hospital from January 2012 to December 2013 were enrolled in this study. Thirty healthy full term newborn infant were used as the con- trols. Contents of serum Cyst - C and urinary microalbum were measured respectively. Urinary routine examination was performed in study group. Results The contents of serum Cyst - C （2.24 ±0.81 mg/L） and urinary microalbu- rain （20.04 ± 10.32 mg/L） in study group were significantly higher than those in the control （0.85 ±0.20 mg/L and2.30 ±1.38mg/L respectively;P 〈0.01 ）. The proportion of urinary routine abnormality （35.0%） was signifi- cantly lower than that of urinary microalbumin （61.7%） and serum Cyst - C abnormalities （ 71.7% ） in study group （P 〈 0.01 ）. Conclusions Serum Cyst - C and urinary microalbumin may serve as indexes in the assessment of early renal impairment in asphyxiated neonates.