细菌转录调控蛋白CarD的研究进展

Progress on CarD,A Bacteria Transcription Regulatory Protein

微生物为适应各种多变的环境,需要通过严紧反应调控rRNA基因的转录表达。细菌CarD含有DNA结合的C端结构域和RNA聚合酶相互作用的N端结构域,作为一种全局调控蛋白,参与多种细胞生理代谢过程,在调控核糖体rRNA转录中发挥着重要的作用。从细菌CarD的蛋白结构、同源蛋白及调控方式等研究进展进行了概述,探讨了CarD蛋白的功能及其调控rRNA转录表达的分子作用机制,以期为相关研究提供参考。

To adapt to diverse environments,microorganism require coordinate transcriptional regulation of rRNA through the stringent response.Bacterial CarD has a C-terminal DNA-binding domain and an N-terminal domain involved in interactions with RNA polymerase,as a global regulator,which involves in many cellular physiological metabolism processes and plays an important role in regulating the ribosome RNA transcription.This paper expounded the progress in studying the protein structure of bacteria CarD,homologous protein and control method,etc..It also discussed the function of CarD protein and its molecular mechanism for regulating rRNA transcriptional expression.