担子菌中甲羟戊酸途径影响萜类物质合成的研究

Studies of Mevalonate Pathway Influence on Biosynthesis of Terpenoids in Basidiomycota

担子菌中具有多种萜类活性物质,这些活性物质对人类的营养和健康有着很重要的影响。甲羟戊酸途径是担子菌合成萜类物质的一条主要途径,萜类物质的含量水平受到甲羟戊酸途径的控制,但是生物细胞内萜类物质的产量很低,并且目前活性萜类物质的化学以及生物合成方法效率低、成本高,因此为了能够更好的增加萜类物质在担子菌细胞内的产量,介绍了担子菌甲羟戊酸途径中乙酰辅酶A、HMG-CoA、甲羟戊酸激酶影响萜类物质的合成作用,旨在通过调控这些物质来增加目标萜类物质的产量。

There are numerous active terpenoids in Basidiomycota cellular.These active substances have important influence on human nutrition and health.Mevalonate pathway,which can govern biosynthesis of some kinds of terpenoids,is an essential path in regulating secondary metabolism in Basidiomycota cells.However,the production of terpenoids in the cell is very low,and the chemical and biological synthesis methods of active terpenoids are with low efficiency and high cost.Therefore,in order to increase the output of terpenoids substances,this paper introduced some key substances,Acetyl-CoA,HMG-CoA,MVK,and their influences on biosynthesis of terpenoids,aiming at improving target terpenoids production by adjusting and controlling these substances.