摘要
目的:为制备色泽白、黏度高的蜣螂壳聚糖,以蜣螂甲壳素为原料,探讨其脱色工艺条件。方法:首先考察脱色剂种类、H2O2浓度、pH值、固液比、反应温度等因素对壳聚糖色泽和特性黏度的影响,继而在单因素试验的基础上,采用L9(34)正交试验法优选H2O2脱色工艺的参数。结果:蜣螂甲壳素脱色的最佳工艺条件为:脱色剂H2O2浓度为15%、固液比1∶15、反应温度为45℃。结论:该工艺稳定可行,脱色效果好,可最大限度保持壳聚糖的高黏度,使其有望成为结肠定位给药的新型载体。
Objective: Decolorization of crude chitin from Catharsius molossus was studied in order to prepare chitosan with white color and high viscosity.Methods: Some factors affecting decolorization such as the kind of decolorant reagent,H2O2 concentration,pH,solid-liquid ratio,temperature and other factors were studied by single factor test and orthogonal design.Results: The best decolorization process of chitin from Catharsius molossus was as follows: treated with 15 times of 15% H2O2 at 45 ℃.Conclusion: The process is stable and feasible.The chitosan from Catharsius molossus might be used as a new carrier of colon-specific drug delivery system.
出处
《中药材》
CAS
CSCD
北大核心
2014年第4期561-564,共4页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金(30902005)
绵阳市科技计划(11F020)
西南科技大学博士基金(10zx7153)
关键词
蜣螂
甲壳素
壳聚糖
脱色
双氧水
Catharsius molossus Linnaeus Chitin Chitosan Decolorization Hydrogen peroxide