蜣螂药渣中甲壳素的脱色工艺研究

Decolorization of Chitin from Catharsius molossus Discards

目的:为制备色泽白、黏度高的蜣螂壳聚糖,以蜣螂甲壳素为原料,探讨其脱色工艺条件。方法:首先考察脱色剂种类、H2O2浓度、pH值、固液比、反应温度等因素对壳聚糖色泽和特性黏度的影响,继而在单因素试验的基础上,采用L9(34)正交试验法优选H2O2脱色工艺的参数。结果:蜣螂甲壳素脱色的最佳工艺条件为:脱色剂H2O2浓度为15%、固液比1∶15、反应温度为45℃。结论:该工艺稳定可行,脱色效果好,可最大限度保持壳聚糖的高黏度,使其有望成为结肠定位给药的新型载体。

Objective： Decolorization of crude chitin from Catharsius molossus was studied in order to prepare chitosan with white color and high viscosity.Methods： Some factors affecting decolorization such as the kind of decolorant reagent,H2O2 concentration,pH,solid-liquid ratio,temperature and other factors were studied by single factor test and orthogonal design.Results： The best decolorization process of chitin from Catharsius molossus was as follows： treated with 15 times of 15% H2O2 at 45 ℃.Conclusion： The process is stable and feasible.The chitosan from Catharsius molossus might be used as a new carrier of colon-specific drug delivery system.