绝经期后女性血尿酸参考区间的建立及与雌激素相关性研究

The Establishment of Serum Uric Acid Reference Ranges and Correlation Between Serum Uric Acid and Estradiol in Postmenopausal Women

目的 建立绝经期后女性血清尿酸参考区间及探讨血清尿酸与雌二醇相关性.方法 收集2013年6月至8月期间于北京大学深圳医院进行健康体检的人群,其中绝经期妇女166名（年龄均＞55岁）,检测血清尿酸、雌二醇,非绝经期女性139名,检测血清尿酸,采用SPSS软件统计分析.结论 绝经期妇女血尿酸95％可信区间为（143.3～492.2 μmol/L）,高于于非绝经期女性（98.6～336.3μmol/L）,差异有显著意义（P＜0.05）,雌二醇与血尿酸呈负相关（r=-0.593,P＜0.01）.结论 各实验室应建立绝经期后女性的血清尿酸参考区间;雌二醇与尿酸呈负相关,可作为高尿酸血症的一项诊疗指标.

Objective To establish the reference ranges of serum uric acid （SUA） and analyze the correlation between serum uric acid and estradiol （E2） in postmenopausal women.Methods 166 postmenopausal women over the age of 55 and 139 non-menopause women were selected,the serum levels of SUA and E2 in these patients were detected.The statistical analysis of the data was performed using SPSS version 16.0 software.Results The 95% confidence interval of serum SUA in postmenopausal women was 143.3-492.2μmol/L）,it was higher than that of non-menopause women （P 〈 0.05）.The serum E2 levels was negatively correlated with SUA （r =-0.593,P 〈0.01）.Conclusion It is necessary to establish postmenopausal-specific reference ranges of serum SUA,there are negative correlation between E2 and SUA.The serum levels of E2 might be used as biomarkers for diagnosis of hyperuricemia in postmenopausal women.