血清C反应蛋白和半乳糖凝集素-1对脑胶质瘤的诊断价值

The Value of Serum C Reactive Protein and Galectin-1 in the Diagnosis of Glioma

目的探讨血清C反应蛋白(CRP)和半乳糖凝集素1含量对于脑胶质瘤的诊断价值。方法分别检测116例健康对照组、103例低级别脑胶质瘤组和138例高级别脑胶质瘤组中C反应蛋白和半乳糖凝集素1的含量。结果与健康对照组比较,低级别脑胶质瘤组和高级别脑胶质瘤组中CRP和半乳糖凝集素-1含量均升高,且差异具有统计学意义;与低级别脑胶质瘤组比较,高级别脑胶质瘤组的CRP和半乳糖凝集素-1含量均升高,且差异具有统计学意义;CRP和半乳糖凝集素-1联合检测区分健康对照组和脑胶质瘤组的诊断灵敏度和特异性分别为91.29%和88.80%,优于单独检测;CRP和半乳糖凝集素-1联合检测区分低级别和高级别脑胶质瘤组的诊断灵敏度和特异性分别为87.55%和87.93%,优于单独检测。结论 CRP和半乳糖凝集素-1联合检测对脑胶质瘤的辅助诊断具有一定的潜在价值。

Objective To explore the diagnostic value of serum C-reactive protein （CRP） and galectin-1 levels in the diagnosis of glioma.Methods The serum levels of C-reactive protein and galectin-1 were detected in 116 healthy control individuals,103 low-grade glioma patients and 138 high-grade glioma patients.Results Compared with the healthy control group,the serum CRP and Galectin-1 levels in the low-grade glioma group and high-grade glioma group showed significantly increased.Compared with the low-grade glioma group,the serum CRP and Galectin-1 levels in the high-grade glioma showed significantly increased.When the C-reactive protein and galectin-1 were used alone and combined diagnosis for distinguishing between healthy control group and the glioma group,the C-reactive protein and galectin joint detection showed better diagnostic value compared to the indicator used alone,its diagnostic sensitivity and specificity were 91.29% and 88.80%.When the C-reactive protein and galectin-1 were used alone and combined diagnosis for distinguishing between low-grade glioma group and high-grade glioma group,C-reactive protein andgalectin joint detection showed better diagnostic value compared to the indicator used alone,its diagnostic sensitivity and specificity were 87.55% and 87.93%.Conclusion The combined detection of C-reactive protein and galectin may be used as a potential diagnostic method for glioma.