期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血清同型半胱氨酸水平与心脑血管疾病的关系探讨 被引量：19

下载PDF
导出
摘要 同型半胱氨酸（Hcy）是一种很重要的氨基酸，即2-氨基-4-硫基丁酸，为一种含硫氨基酸，是甲硫氨酸代谢的中间产物，大部分Hcy在血液中通过二硫键与蛋白质结合，只有小部分的游离Hcy参与到循环中。流行病调查资料证明血清Hcy水平升高是心脑血管疾病独立的危险因素，血清Hcy与颅动脉、
作者 张亚文 李继恩 秦蕾 丁国玉 朱颖
机构地区 吉林油田总医院检验科
出处 《标记免疫分析与临床》 CAS 2014年第3期338-339,共2页 Labeled Immunoassays and Clinical Medicine
基金 国家863计划课题资助 NO 2011AA02A111
关键词 同型半胱氨酸 脑梗塞 高血压 冠心病
分类号 R54 [医药卫生—心血管疾病] R589 [医药卫生—内分泌]
  • 相关文献

参考文献6

  • 1Montalescot G, Ankri A, Blacker J, et al. Plasma homocysteine and the extent ofatherosclerosis in patients with coronary artery disease . Int J Car, 1997,60 ( 3 ) : 295- 300.
  • 2Biselli P M, Guerzoni A R, de Godoy M F, et al. Genetic polymorphisms involved in folate metabolism and concentrations of methylamine acid and folate on plasma homocysteine and risk of coronary artery disease . Thrombi thrombolysis, 2009, 13 ( 2 ) : 201 - 204.
  • 3Akasaka K, Akasaka N, Di Luozzo G, et al. Homoeysteine promotes 38-dependent chemotaxis in bovine aortic smooth muscle cell . Vase surg,2007,41 (3) :517-522.
  • 4Au-Yeung K K,Yip J C, Siow Y L, et al. Folio acid homocysteine induced superoxide anion production . Can J Physiologic pharmacol, 2006,84 ( 1 ) : 141 - 147.
  • 5Kirilow G, Zacharieva S, Alexandrov A S, et al. Miter V. In creased plasma endothelia level as an endothelial marker of cardiovascular risk in patients : A comparison with plasma homocysteine . Methods Find Exp Clinical Pharmacology, 2009,31 (7) :457-461.
  • 6王立新,何青芳,俞敏.同型半胱氨酸与高血压的相关性研究[J].中国预防医学杂志,2008,9(5):416-417. 被引量：36

二级参考文献12

  • 1叶德寿,李英,李东野,钱文浩,于浩,夏勇,张超群.血浆同型半胱氨酸与原发性高血压的流行病学研究[J].临床心血管病杂志,2005,21(9):536-538. 被引量：18
  • 2高静,董振南,田亚平.循环酶法测定血清同型半胱氨酸的临床应用研究[J].中华检验医学杂志,2006,29(3):199-202. 被引量：43
  • 3Ozkan Y, Ozkan E, Simsek B. Plasma total homocysteine and cysteine levels as cardiovascular risk factors in coronary heart disease. Int J Cardiol, 2002, 82:267 -277.
  • 4Harker LA, Ross R, Slichter S J, et al. Homocysteine - induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest, 1976, 58:731 -734.
  • 5Tawakol A, Omland T, Gerhard M, et al. Hyperhomocyst (e) inemia is associated with impaired endothelium -dependent vasodilation in humans. Cirulation, 1997, 95 : 1119 - 1121.
  • 6Upchurch GR Jr, Welch GN, Fabian AJ, et al. Homocyst (e) ine decreases bioavailable nitric oxide by a mechanism invooolving glutathione peroxidase. J Biol Chem, 1997, 272: 17012 - 17017.
  • 7Yamamoto M, Hara H, Adachi T. Effects of homecysteine on the binding of extracellular - superoxide dismutase to the endothelial cell surface. FEBS Lett, 2000, 456:159 -162.
  • 8Khajuria A, Houston DS. Induction of monocyte tissue factor expression by homocysteine: A possible mechanism for thrombosis. Blood 2000, 96 : 966 - 972.
  • 9Quere I, Habib A, Tobelem G, et al. Inhibition of cyclooxxygenase activity in human endothelial cells by homocysteine. Adv Prostaglandin Thromboxane Leukot Res, 1995, 23:397 -399.
  • 10Stander JS, Osborne JA, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated by endothelium -derived relaxing factor and related oxides of nitrogen. J Clin Invest, 1993, 91 :308 -318.

共引文献35

同被引文献179

  • 1胡春松,胡大一.高血压治疗原则的进展及我国高血压治疗策略的特点与变化[J].中国中西医结合杂志,2007,27(4):380-382. 被引量：59
  • 2陈文彬,潘祥林.诊断学[M].8版.北京:人民卫生出版社,2013:247-252.
  • 3李建平,霍勇,刘平,秦献辉,关德明,葛均波,胡健,王燕妮,张馥敏,毛广运,徐希平.马来酸依那普利叶酸片降压、降同型半胱氨酸的疗效和安全性[J].北京大学学报（医学版）,2007,39(6):614-618. 被引量：390
  • 4Biselli PM, Guerzoni AR, de Goday MF, et al. Genetic polymor- phyisms involved in folate metabolism and concentrations of me- thymalane acid and folateon plasma homocysteine and risk of cor- onary artery disease[J]. J Thromb Thrombolysis,2010,29 (1): 32-40.
  • 5Akasaka K,Akasaka N, Di Luozzo G, et al. Homoeysteine pro- motes p38-dependent ehemotaxis in bovine aortic smooth cell[J]. J Vase Surg, 2005,41 (3) : 517-522.
  • 6Feig DI ,Johnson RJ. Hyperuricemia in childhood primary Hyper- tension[J]. Hypertension, 2003,42 (3) : 247-252.
  • 7Cotlarciuc I, Malik R, Holliday EG, et al. Effect of genetic variants associated with plasma homocysteine levels on stroke risk [ J]. Stroke ,2014,45 ( 7 ) : 1920 - 1924.
  • 8Motegi S, Toki S, Yamada K, et al. Elevated plasma homocysteine level is possibly associated with skin sclerosis in a series of Japanese patients with systemic sclerosis[ J]. J Dermatol,2014,41 ( 11 ) :986 -991.
  • 9Wright CB,Paik MC,Brown TR, et al. Total homocysteine is associ- ated with white matter hyperintensity volume : the northern manhattanstudy [ J]. Stroke ,2005,36(6) : 1207 - 1211.
  • 10Batra S, Perelman N, Luck LR, et al. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival[ J ]. Lab Invest,2003,83 ( 10 ) : 1477 - 1487.

引证文献19

二级引证文献184

标记免疫分析与临床
2014年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部