老年患者静脉滴注利巴韦林致过敏性休克

Anaphylactic shock caused by Ⅳ infusion of ribavirin in senile patient

1例84岁男性患者因带状疱疹给予静脉滴注利巴韦林韦0.4 g+5%葡萄糖注射液250 ml。静脉滴注约10 min时患者出现胸闷、气喘、呼吸困难、血压降至70/40 mmHg(1 mmHg=0.133 kPa),立即停药给予吸氧、非那根25 mg肌内注射、地塞米松10 mg静脉推注、肾上腺素1 mg皮下注射,10 min后症状缓解。2 h后血压升至140/85 mmHg。

A 84-year-old man received an IV infusion of ribavirin 0.4g in 5% glucose 250 ml for herpes zoster.The patient developed pale, chest distress, short of breath with a BP of 70 /40 mm Hg after ten minutes＇ infusion. The infusion was stopped immediately. Oxygen inhalation therapy, adrenalin, dexamethasone, phenergan were given. The patient＇s symptoms improved. Two hours later, the blood pressure rose to 140 /85 mm Hg.