曲美他嗪联合美托洛尔治疗伴频发室性早搏冠心病的临床疗效探讨

目的：观察和探讨曲美他嗪联合美托洛尔治疗伴频发室性早搏冠心病的临床疗效。方法：选取2010年1月至2013年12月我院心内科专家门诊及住院伴有频发室性早搏冠心病患者68例,随机分为治疗组35例与对照组33例,其中治疗组给予曲美他嗪并美托洛尔进行治疗,对照组给予美托洛尔治疗。结果：经治疗后,治疗组显效5例,有效24例,总有效率82.9%;对照组显效2例,有效20例,总有效率66.7%。治疗组总有效率明显高于对照组（P〈0.05）,具有统计学意义。结论：曲美他嗪联合美托洛尔治疗伴频发早搏冠心病患者,其效果优于美托洛尔单独用药,且未见不良反应,患者耐受性好,值得推广应用。

Objective： To observe and study of trimetazidine combined with metoprolol for treatment of coronary heart disease complicated with frequent premature ventricu- lar beats clinical curative effect. Methods： from January 2010 to December 2013 in our hospital from coronary heart disease complicated with frequent premature ventricular contraction in patients with a total of 68 patients, divided into the treatment group 35 cases and control group 33 eases, in which, the treatment group patients give trimetazi- dine combined with metoprolol for treatment; patients in control group were only given simple metoprolol. Results： after treatment, the treatment group excellent in 5 cases, effective in 24 cases, the total effective rate was 82.9 %. the control group excellent in 2 cases, effective in 20 cases, the total effective rate was 66.70%. The total effective rate of treatment group was significantly higher than that of control group. And the differences are significant （ P 〈 0.05 ）, with statistical significance. Conclusion= the effect of trimetazidine combined with metoprolol for treatment of coronary heart disease complicated with frequent premature ventricular beats better than only metoprolol for treat, No any adverse reactions and good tolerability in the treatment, is worth widely used.