自拟除湿散结汤联合他扎罗汀凝胶及窄谱中波紫外线治疗泛发性结节性痒疹

Treating generalized nodular prurigo with Chushi Sanjie decoction plus tazarotene gel and narrow-band UV

目的:观察口服自拟除湿散结汤联合他扎罗汀凝胶外用及窄谱中波紫外线照射治疗泛发性结节性痒疹的疗效。方法:将入选的112例泛发性结节性痒疹患者采用随机方式分为治疗组(A组,n=38),给予外用0.1%他扎罗汀凝胶,每晚1次,并用窄谱中波紫外线(NB-UVB)照射,隔日1次;对照1组(B组,n=36),单纯给予他扎罗汀凝胶外用;对照2组(C组,n=38),单纯给予NB-UVB照射;3组患者均口服自拟除湿散结汤。4、8周后分别评价疗效,疗程结束12周随访复发情况。结果:治疗1个疗程后,3组有效率分别为68.4%、44.4%、47.4%,3组间比较差异有显著意义(P<0.05),A组疗效优于B组和C组;治疗2个疗程后,3组有效率分别为89.5%、61.1%、63.2%,3组间比较差异有显著意义(P<0.01),A组疗效明显优于B组和C组。A组复发率也明显低于B组和C组。结论:口服自拟除湿散结汤联合他扎罗汀凝胶外用及窄谱中波紫外线照射治疗结节性痒疹疗效显著。

Objective： To observe clinical effects of Chushi Sanjie decoction plus tazarotene gel and narrow-band UV on treating generalized nodular prurigo. Methods： 112 patients were randomly divided into two groups, the treatment group of 38 cases named A was given 0.1% tazarotene gel for every night and irradiated with a narrow-band UVB （NB-UVB） for every other day; the control group 1 named B was given tazarotene gel solo; the control group 2 named C was given NB-UVB; all groups were treated with Chushi Sanjie decoction, evaluating the effects in 4 and 8 weeks. Results： The total efficacy in three groups were 68.4%, 44.4%, 47.4% after one treatment with a significant difference （P〈0.05）, clinical effects in A group were better; the rate was 89.5%, 61.1%, 63.2% after two treatment with a high significant difference （P〈0.05）, clinical effects in group A were better with a low recurrence. Conclusion： Chushi Sanjie decoction plus tazarotene gel and narrow-band UV has good clinical effects on treating generalized nodular prurigo.