RKIP和MMP-9在结直肠癌中的研究进展

Advances in Studies on RKIP and MMP-9 in Colorectal Cancer

Raf激酶抑制蛋白(RKIP)是磷脂酰乙醇胺结合蛋白家族成员之一,可抑制肿瘤细胞转移,与肿瘤的发生、发展密切相关。基质金属蛋白酶-9(MMP-9)是一种能降解细胞外基质的内肽酶,在肿瘤侵袭、转移过程中发挥重要作用。本文就RKIP和MMP-9在结直肠癌中的研究进展作一综述。

Raf kinase inhibitor protein （RKIP）is a member of the phosphatidylethanolamine-binding protein family, which can inhibit the metastasis of tumor cells and is closely associated with the occurrence and development of tumor. Matrix metalloproteinase-9 （MMP-9）is a endopeptidase that can degrade extracellular matrix and plays an important role in invasion and metastasis of tumor.This article reviewed the advances in studies on RKIP and MMP-9 in colorectal cancer.