经尿道精囊镜联合非那雄胺治疗顽固性血精的疗效观察

Transurethral seminal vesiculoscopy combined with finasteride for recurrent hematospermia

目的:探讨经尿道精囊镜技术联合非那雄胺治疗顽固性血精的临床有效性。方法:总结分析2009年10月至2013年6月治疗的32例顽固性血精患者临床资料。所有患者经非那雄胺(5 mg/d)治疗2周后,硬膜外麻醉下Wolf F6/7.5精囊镜经尿道进行检查和治疗,术后继续应用非那雄胺(5 mg/d)治疗2周。定期随访,观察血精消失情况及有无并发症。结果:32例患者精囊镜检手术均获成功,其中单纯性精囊炎16例、精囊炎合并精囊结石10例、精囊囊肿1例、精囊息肉2例、精囊脓肿3例。精囊镜检手术时间20～51(31.0±5.2)min。1例患者术后并发急性附睾炎,经抗炎治疗好转;3例术后4周内轻度乳房胀痛不适。所有患者均无尿失禁、尿道狭窄、直肠损伤、逆行射精、性功能障碍等并发症。1例失访,31例术后随访6个月至2年,29例治愈,2例复发。结论:经尿道精囊镜联合短疗程应用非那雄胺治疗顽固性血精安全、有效。

Objective： To evaluate the clinical effectiveness of transurethral seminal vesiculoscopy （TUSV） combined with finasteride in the treatment of recurrent hemospermia. Methods ： This study included 32 patients with recurrent hematospermia, with the disease course of 3 months to 4 years. After administration of finasteride at 5 mg/d for 2 weeks, the patients underwent TUSV for both exploration of the eanses and treatment, followed by medication with finasteride at the same dose for another 2 weeks. Postoperative follow-up was conducted for observation of the outcomes and complications. Results ： TUSV was successfully accomplished in all the 32 cases, which revealed 16 cases of seminal vesieulitis, 10 seminal calculi, 1 seminal vesicle cyst, 2 seminal vesicle polyps, and 3 seminal vesicle abscess. The operative time was 20 to 51 （ 31.0 ± 5.2 ） minutes. Postoperative complications included 1 case of acute epididymitis and 3 cases of breast discomfort within the first 4 weeks. No incontinence, urethral stricture, rectal injury, retrograde ejaculation, and sexual dysfunction occurred postoperatively. All the patients but 1 were followed up for 6 months to 2 years. Twenty-nine of the cases were cured, and 2 experienced recurrence. Conclusion ： Transurethral seminal vesiculoscopy combined with finasteride is safe and effective for the treatment of recurrent hemospermia.