组蛋白精氨酸甲基化与斑马鱼早期发育

Histone Arginine Methylation and Early Development in Zebrafish

发育是由基因的特定时空表达模式来调控的,其表观遗传机制已越来越受到关注。组蛋白精氨酸甲基化是一种重要的翻译后修饰,由蛋白质精氨酸甲基化酶催化产生,对染色体的结构与功能具有重要调控作用。不同位点的精氨酸甲基化与其相邻位点的翻译后修饰具有复杂的对话机制,并可招募或阻碍相关效应分子的结合,进而导致转录激活或抑制。斑马鱼作为一种重要的发育生物学研究模式动物,已为蛋白质精氨酸甲基化酶在早期发育过程中的生理功能的研究提供了大量资料。该文对组蛋白精氨酸甲基化的产生、对话调控机制及其对斑马鱼早期发育调控功能的研究进行综述。

Development is determined by spatial and temporal gene expression patterns, the epigenetic mechanisms of which has been paid more and more attention. Histone arginine methylation is post-translational modification （PTM） generated by protein arginine methyltransferases, and regulates the structure and function of chromosome. There are complicated cross talks between PTMs at different R sites and its adjacent sites, which lead to expression activation and repression by recruiting or blocking the relative effectors. Zebrafish is an important model in development study, and has contributed to the physiological roles of protein arginine methyltransferases. This review will summarize the generation of histone arginine methylation, its cross talk with other PTMs, and its physiological roles in early development of zebrafish.