肺隐球菌病患者免疫状态与肺CT表现及病理的相关性

The Correlation Research of the Immune Status, CT Performance and Histological Manifestations of Pulmonary Cryptococcosis

目的探讨肺隐球菌病(PC)患者免疫状态与肺部CT征象和病理的相关性。方法回顾性分析50例PC患者的临床和影像学资料。结果有基础疾病与无基础疾病组比较,单发病灶和结节/肿块型在无基础病PC组中更常见(P值分别为<0.001和0.016)。"支气管充气征"、"晕征"、"空洞"是最常见的PC影像征象,出现频率最高,分别为66%,54%,26%。13例出现空洞的病例中,8例空洞壁表现为均匀强化。9例空洞合并有"支气管充气征",其中有6例其空洞与支气管相通。不同免疫状态的PC患者中,其CT征象无统计学差异。结论随着机体免疫受损程度的增加,肺隐球菌感染病灶越弥散。"支气管充气征"、"晕征"、"空洞"是肺隐球菌病有诊断意义的影像征象。

Objective To explore the correlation among the immune status, CT performance and histological manifestations of pulmonary cryptococcosis （PC）. Methods The clinical and CT manifestations of 50 patients with PC were retrospectively analyzed. Results In the comparison of the group with and without underlying disease,single lesion and nodular/mass type were more common in the latter（P〈0.001,P=0.016,respectivel y）. The ＂air bronchogram＂, ＂halo sign＂ and ＂cavity＂ come out more often （66%, 54%, 26%respectively）.Of the 13 cases come out with＂cavity＂, 8 of the cavity wall were even enhanced.9 cases combine with ＂air bronchogram＂. Among the 9 cases,6 come out that the cavity communicates with the bronchial. The CT signs have no statistical difference in patients with different immune status. Conclusion With the increase of the body＇s immune damage, the CT manifestations of pulmonary cryptococcosis turn out more diffuse. The＂air bronchogram”,“halo sign”and“cavity”are of diagnostic significance.