P57^kip2蛋白在肝门部胆管腺癌中的表达及其临床意义

The expression of P57^kip2 and its clinical significance in hilar bile duct adenocarcinoma

目的探讨P57^kip2蛋白在肝门胆管腺癌中的表达及临床意义。方法采用免疫组织化学方法检测37例肝门胆管腺癌组织（胆管腺癌组）和32例正常胆管组织（对照组）中P57^kip2的表达，分析其与临床病理的关系。结果胆管癌组织中P57^kip2蛋白表达率为43．2％（16／37），明显低于正常胆管组织中的表达率87．5％（28／32，P〈0．01）；P57^kip2的表达与患者性别、年龄、CA19-9水平无关（P〉0．05），与有无淋巴结转移、周围组织浸润、分化程度有关（P〈0．05）。结论P57^kip2参与肝门胆管癌的发生、发展，可作为判定肝门胆管癌恶性程度的重要生物学指标。P57^kip2可能在肝门胆管癌的侵袭和转移过程中起重要作用。检测P57^kip2对肝门胆管腺癌的诊断及预后有着重要意义。

duct ad Objective To study the expression of P57^kip2 a. Methods The expressions of P57^kip2 in and its clinical significance in hilar bile hilar bile duct adenocarcinoma tissues （37 cases） and normal bile duct tissues （32 cases） were determined by immunohistochemical SP methods. The relations between the expression levels of P57^kip2 with clinicopathologic parameters were analyzed. Results The positive rate of P57^kip2 was 43.2%（16/37） in bile duct adenocarcinoma, while it was 87.5% （28/32） in normal duct tissues （P 〈0. 01 ）. The expression level of P57^kip2 in adenocarcinoma showed no significant association with gender, age or CA19-9 level （P 〉 0.05）, but they were significantly related with lymph node metastasis, invasion and degree of differentiation （P 〈 0. 05 ）. Conclusions P57^kip2 is associated with the occurrence and development of hilar bile duct adenocarcinoma. It may play an important role in invasion and metastasis of hilar bile duct adenocarcinoma. The P57 protein can be used as an index to diagnose hilar bile duct ade