术中放射性粒子植入治疗晚期胰腺癌的疗效

Intra-operative implantation of Ⅰ^125 seeds to treat advanced pancreatic cancer

目的探讨术中Ⅰ^125粒子植入对晚期胰腺癌的治疗效果。方法回顾性分析我院2009年1月至2013年6月28例行术中Ⅰ^125粒子植入治疗的晚期胰腺癌患者的临床资料，并将其与我院同期保守治疗的晚期胰腺癌患者（n=136）资料进行比较。结果28例行术中Ⅰ^125粒子植入的晚期胰腺癌患者，肿瘤平均最大直径为（5．7±1．7）cm，术中平均植入粒子50粒。术后无胰瘘及出血等并发症发生，无围手术期死亡。24例患者获得随访，随访率为85．7％。粒子植入组患者治疗后1个月、半年、1年生存率分别为100％、70．8％、26．9％，平均生存时间为（9．9±1．4）个月，明显高于保守治疗对照组。结论对于不能行根治性切除的晚期胰腺癌患者，放射性粒子植入术是一种有效的治疗手段。

Objective To study the clinical efficacy of intra-operative implantation of 1122 seeds to treat advanced pancreatic cancer. Methods We retrospectively analyzed the clinical data of 28 patients who underwent intra-operative implantation of Ⅰ^125 between January 2009 and June 2010 to treat advanced pancreatic cancer. Patients who received conservative treatment （n=136） at the same period were used as the control group. Results The mean tumor diameter was （5. 7 ± 1.7） cm. The average number of implanted seeds were 50. There were no patients who suffered from pancreatic fistula or post-operative bleeding, and no patient died from the treatment. Twenty-five patients were regularly followed up, and the follow-up rate was 85. 7%. The survival rates at one month, half a year and one year were 100% , 70. 8% and 26.9% , respectively. The average survival time was （9. 9 ± 1.4）months. The survival data were significantly higher than that in the control group. Conclusion Intra-operative implantation of Ⅰ^125 seeds was an efficacious treatment for patients with advanced pancreatic cancer.