内镜止血联合大剂量质子泵抑制剂治疗急性非静脉曲张性上消化道出血的临床研究

Clinical research of endoscopic hemostasis combined with high dose proton pump inhibitors(PPIs) in treatment for acute non-variceal upper gastrointestinal bleeding(ANVUGIB)

目的探讨内镜止血联合大剂量质子泵抑制剂治疗急性非静脉曲张性上消化道出血的临床效果。方法选取本院2011年10月～2013年10月诊治的急性非静脉曲张性上消化道出血患者148例，根据治疗方案分为两组，74例患者采用大剂量质子泵抑制剂治疗为对照组，74例患者采用内镜止血联合大剂量质子泵抑制剂治疗为观察组，比较两组患者的止血效果与预后情况。结果观察组患者止血时间、输血量、住院时间均明显小于对照组，观察组患者剖腹手术率、再出血率均明显低于对照组，差异均有统计学意义（P〈0．05）。结论内镜止血联合大剂量质子泵抑制剂是治疗急性非静脉曲张性上消化道出血的有效方法，可明显缩短患者的止血时间，显著提高疾病的治疗效果，值得临床推广使用。

Objective To investigate clinical effect of endoscopic hemostasis combined with high dose PPIs in treatment for ANVUGIB. Methods 148 patients with ANVUGIB were selected in hospital from October 2011 to October 2013. According to treatment, patients were divided into two groups. 74 patients treated high dose PPIs as control group. 74 patients treated endoscopic hemostasis combined with high dose PPIs as observation group. Hemostatic effect and prognosis were compared between two groups. Results Hemostatie time, volume of blood transfusion, hospitalization time in observation group were significantly less than control group. Caesarean operation rate and rebleeding rate in observation group were significantly lower than control group. Differences were statistically significant （P 〈 0.05）. Conclusion Endoscopic hemostasis combined with high dose PPIs are effective methods in treatment for ANVUGIB, which can significantly shorten hemostatic time and improve treatment effect. Endoscopic hemostasis combined with high dose PPIs are worthy of clinical use.