妊娠期高血压疾病孕妇凝血功能的对照研究

Control study of coagulation function of pregnant women with hypertensive disorders complicating pregnancy

目的对妊娠期高血压疾病孕妇凝血功能进行对照研究。方法选取2011年7月～2013年6月在我院妇产科住院分娩的妊娠期高血压疾病孕妇272例作为研究对象，分为3个亚组；随机选取来本院产检的正常孕妇55例作为对照组，对凝血功能进行测定。结果研究组Ⅰ与对照组比较，PT缩短显著，APTT和TT延长（P〈0．05），而两组INR比较，差异不显著。两组Fbg、血小板和红细胞比积比较，差异有统计学意义（P〈0．05）。分组比较，PT差异无统计学意义（P〉0．05），APTT和TT有显著性延长（P〈0．05），Fbg有显著性减少（P〈0．05）。D-二聚体升高的百分率，研究组明显高于对照组，差异有统计学意义（P〈0．05）。而研究组Ⅰ、Ⅱ、Ⅲ组间D-二聚体升高的百分率比较差异无统计学意义（P〉0．05）。结论妊娠期高血压疾病患者具有较高的凝血状态，且存在血管内凝血消耗的情况。

Objective To conduct control study of coagulation function of pregnant women with hypertensive disorders complicating pregnancy. Methods 272 pregnant women with hypertensive disorders complicating pregnancy who delivered in the gynecology and obstetrics department of our hospital from July 2011 to June 2013 were selected as the study subjects and divided into 3 subgroups. Fifty-five normal pregnant women who received antenatal examination in our hospital were selected as the control group. Their coagulation function was measured. Results Compared to the control group, the study group I had significantly shortened PT and prolonged APTT and TT （P 〈 0.05）, but the two groups were not significantly different in INR. The two groups were significantly different in Fbg, blood platelet and hematocrit （P 〈 0.05）. The subgroups were not significantly different in PT （P 〉 0.05）, and had significantly prolonged APTT and TT （P 〈 0.05） and significantly reduced Fbg（P 〈 0.05）. Regarding to the percent of D- dimer increase, the study group was significantly higher than the control group, with significant difference （P 〈 0.05）. But the study group Ⅰ, Ⅱ and In were not significantly different in the percent of D-dimer increase （P 〉 0.05）. Conclusion The patients with hypertensive disorders complicating pregnancy have high coagulation state and intravascular coagulation consumption situation.