阿立哌唑和利培酮对首发精神分裂症患者记忆功能的影响

E fficacy of Aripiprazole and Risperidone on Memory Function in Patients with Schizophrenia

目的探讨阿立哌唑和利培酮对首发精神分裂症患者记忆功能的影响。方法 112例首发精神分裂症患者随机分成阿立哌唑组和利培酮组,每组56例。在治疗前和治疗12周末采用韦氏记忆量表-第三版的空间广度测验(WMS-ⅢSST)、霍普金斯词汇学习测验-修订版(HVLT-R)、简单视觉空间记忆测验-修订版(BVMT-R)分别对工作记忆、言语记忆和视觉记忆领域进行评定。结果在治疗前,两组的WMS-ⅢSST HVLT-R和BVMT-R得分比较均无统计学意义(P>0.05)。在治疗12周后,两组的HVLT-R和BVMT-R得分较治疗前比较均有统计学意义(P<0.05)而治疗后两组间比较无统计学意义(P>0.05);阿立哌唑组在治疗后的WMS-ⅢSST得分较治疗前显著增加(P<0.05),且治疗后两组间比较有统计学意义(P<0.05),而利培酮治疗前后WMS-ⅢSST得分比较无统计学意义(P>0.05)。结论阿立哌唑和利培酮对首发精神分裂症患者记忆功具有改善作用,阿立哌唑对某些记忆功能改善优于利培酮。

Objective To explore the efficacy of aripiprazole and risperidone on memory function in patients with schizophrenia. Methods 112 first-episode patients with schizophrenia were randomized to aripiprazole group（n=56） and risperidone group（n=56）. All subjects were assessed with the Wechsler Memory Scale-ⅢSpatial Span Task（WMS-Ⅲ SST）, the Hopkins Verbal Learning Test-Revised（HVLT-R） and The Brief Visuospatial Memory Test-Revised（BVMT-R）.Results Both groups showed no statistical significance in WMS-Ⅲ SST, HVLT-R and BVMT-R scores in the baseline（P0.05）.The performances after 12 weeks of treatment in the both groups was higher than those in the baseline in all tests（P0.05） except for the WMS-III SST in the risperidone group（P0.05）.After treatment, there was no significant difference between the two groups（P0.05）.Aripiprazole group was increased significantly compared with before treatment after treatment WMS-Ⅲ SST score（P0.05）, and after treatment there was a statistical significance between the two groups（P0.05）.Conclusion Memory impairments in the patients with first-episode schizophrenia was improved by aripiprazole and risperidone, and effect of aripiprazole on certain memory functions was better than those of risperidone.