198株屎肠球菌的临床分布及耐药性分析

198 Strains of Excrement Enterococcus Clinical Distribution and Drug Resistance Analysis

目的了解医院屎肠球菌(EFM)的临床分布及耐药状况,为临床治疗与合理使用抗菌药物提供参考。方法将临床分离的屎肠球菌进行培养鉴定,采用纸片扩散法(K-B法)进行药物敏感试验。结果分离到198株屎肠球菌,主要来自于尿液、痰液和粪便标本,分别占50.0%、30.8%和7.6%,标本主要分离于重症监护病房(ICU)、泌尿外科和呼吸内科。屎肠球菌对多种抗菌药物耐药,对万古霉素、替考拉宁的耐药率较低,分别为1.0%和2.5%。屎肠球菌对利奈唑胺敏感率为100%。结论屎肠球菌可引起临床各类感染,且多耐药率高,治疗困难,应引起临床高度重视。

Objective To understand the nosocomial Enterococcus faecium（EFM） clinical distribution and drug resistance,and provide reference for rational use of antibacterial drugs and clinical treat-ment. Methods The clinical isolates of Enterococcus faecium were cultured and identified, using disk diffusion method （K-B） for drug sensitivity test. Results 198 isolates of Enterococcus faeci-um, mainly from urine, sputum and stool samples, accounted for 50%,30.8% and 7.6%,were main-ly isolated from intensive care unit（ICU）, and Respiratory Department of Internal Medicine Depart-ment of urology. Antimicrobial resistance in Enterococcus faecium, resistance to vancomycin, te-icoplanin is a low rate, respectively 1% and 2.5%. Enterococcus faecium to linezolid sensitive rate is 100%.Conclusions Enterococcus faecium clinical types can cause infection, and the multi drug resistance rate high, difficult to treat, should arouse more attention in clinic.