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miR-26a、C-erBb-2在胃癌中的表达及其相关性研究 被引量：1

Correlation Research miR-26a, C-erBb-2 Expression in Gastric Cancer
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摘要 目的探讨miR-26a、C-erBb-2的表达与胃癌临床病理特征之间的关系及其相关性。方法运用荧光定量RTPCR法检测30例胃癌组织标本对应的正常胃黏膜标本中miR-26a的表达水平;运用免疫组化方法检测30例胃癌组织标本对应的正常胃黏膜标本中C-erBb-2蛋白的表达水平。结果 (1)胃癌组织中miR-26a表达明显低于正常胃粘膜(P<0.05);胃癌组织中C-erBb-2蛋白表达高于正常胃黏膜(P<0.05);(2)胃癌组织中miR-26a的表达与其淋巴结转移、肿瘤病理分期有关(P<0.05);胃癌中C-erBb-2蛋白的表达与肿瘤分期和淋巴转移有关(P<0.05);(3)胃癌组织中miR-26a相对表达水平与胃癌组织中C-erBb-2蛋白表达呈负相关。结论 miR-26a和C-erBb-2可能参与了胃癌的发生发展;miR-26a可能为胃癌早期诊断、判断预后的新靶标。
作者 陈刚 王芬 仇玮 沈志力 周荣平
机构地区 南京医科大学附属江宁医院肿瘤科
出处 《现代诊断与治疗》 CAS 2013年第19期4323-4325,共3页 Modern Diagnosis and Treatment
关键词 miR-26a C-ERBB-2 胃癌
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

  • 1Cheng AM,Byrom MW,Shelton J,et al.Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis[J].Nucleic Acids Res,2005,33(4):1290-1297.
  • 2Xu P,Guo M,Hay BA.MicroRNAs and the regulation of cell death[J].Trends Genet,2004,20(12):617-624.
  • 3Karp X,Ambros V.Encountering microRNAs in cell fate signaling[J].Science,2005,310(5752):1288-1289.
  • 4Chen CZ,Li L,Lodish HF,et al.MicroRNAs modulate hematopoietic lineage differentiation[J].Science,2004,303(5654):83-86.
  • 5Poy MN,Eliasson L,Krutzfeldt J,et al.A pancreatic is let2 specific microRNA regulates insulin secretion[J].Nature,2004,432(7014):226-230.
  • 6Bang YJ,Van Cutsem E,Feyereislova A,et al.Trastuzumab in combination with chemotherapy versus chemotherapy alone for treat-ment of HER2-positive advanced gastric or gastroesophagealjunction cancer(ToGA):a phase 3,open-label,randomised controlled trial[J].Lancet,2010,376(9742):687-697.
  • 7YANAIHARA N,CAPLEN N,BOWMAN E,et a1.Unique microRNA molecular profiles in lung cancer diagnosis and prognosis[J].Cancer Cell,2006,9(3):189-198.
  • 8VISUNE R,PALLANTE P,VECCHIONE A,et a1.Specific microRNA are downregulated in human thyroid anaplastic carcinomas[J].Oncogene,2007,26(54):7590-7595.
  • 9刘友平,李娟,代荣阳,段春燕,陈绍坤,严冬梅,陈川宁,李洪.miR-26a mimics转染人肝癌细胞株HepG2的表达蛋白质组分析[J].中国病理生理杂志,2011,27(2):367-370. 被引量：4
  • 10Goueli BS,Janknecht R.Upregulation of the catalytic telomerasesubunit by the transcription factor ER81 and oncogenic HER2/Neu,Ras or Raf[J].Mol Cell Biol,2004,24(1):25-35.

二级参考文献17

  • 1王旭丹,杨惠玲,郭禹标,梁志慧,赵睿颖,夏云飞,苏勇,Mong-Hong Lee,王瑾,郑芹.不同辐射抗拒鼻咽癌细胞微小RNA差异表达的研究[J].中国病理生理杂志,2007,23(6):1045-1048. 被引量：25
  • 2薛惠平,倪培华,吴洁敏,孙建华,童菊芳.细胞周期蛋白E2基因mRNA在胃癌组织中的表达[J].上海交通大学学报（医学版）,2007,27(1):95-98. 被引量：3
  • 3Calin GA,Sevignani C,Dumitru CD,et al.Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers[J].Proc Natl Acad Sci USA,2004,101(9):2999-3004.
  • 4Yanaihara N,Caplen N,Bowman E,et al.Unique microRNA molecular profiles in lung cancer diagnosis and prognosis[J].Cancer Cell,2006,9(3):189-198.
  • 5Visune R,Pallante P,Vecchione A,et al.Specific microRNA are downregulated in human thyroid anaplastic carcinomas[J].Oncogene,2007,26(54):7590-7595.
  • 6Kota J,Chivukula RR,O'Donnell KA,et al.Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model[J].Cell,2009,137(6):1005-1017.
  • 7Murakami Y,Yasuda T,Saigo K,et al.Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues[J].Oncogene,2006,25(17):2537-2545.
  • 8Zhang B,Pan X,Cobb GP,et al.microRNAs as oncogenes and tumor suppressors[J].Dev Biol,2007,302(1):1-12.
  • 9Hsiang CH,Tunoda T,Whang YE,et al.The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells[J].Prostate,2006,66(13):1413-1424.
  • 10Loeb KR,Kostner H,Firpo E,et al.A mouse model for cyclin E-dependent genetic instability and tumorigenesis[J].Cancer Cell,2005,8(1):35-47.

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现代诊断与治疗
2013年 第19期

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