多巴胺与去甲肾上腺素治疗感染性休克患者的临床疗效比较

Clinical effect comparation of dopamine and norepinephrine in the treatment of patients with septic shock

目的比较多巴胺与去甲肾上腺素治疗感染性休克的临床疗效。方法将我院收治的86例感染性休克患者随机分为多巴胺治疗组(DA组)和去甲肾上腺素治疗组(NE组)各43例,观察两组患者治疗6h后的动脉血乳酸、平均动脉压(MAP)以及混合静脉血氧饱和度(SvO2)的变化情况。结果治疗后NE组患者的动脉血乳酸、MAP以及SvO2水平较DA组有显著改善,组间差异有统计学意义(P<0.05),NE组疗效优于DA组。结论去甲肾上腺素治疗感染性休克的临床疗效优于多巴胺。

Objective To compare the clinical effect of dopamine and norepinephrine in the treatment of septic shock. Methods 86 cases of patients with septic shock in our hospital were randomly divided into dopamine treatment group （group DA） and norepinephrine treatment group （NE group）, 43 cases in each group, observed arterial blood lactate, mean arterial pressure （MAP） and mixed venous oxygen saturation （the changes of SvO2） of patients in the two groups after treatment 6h. Results After treatment, the arterial blood lactic acid, MAP and SvO2 levels of patients in group NE were significantly improved, better than that in DA group,the differences between two groups was statistically significant （P〈0.05）,the clinical effect of patients in NE group was more effective than DA group. Conclusion The clinical effect of norepinephrine in the treatment of patients with septic shock is better than dopamine, more suitable for clinical treatment of septic shock.