糖尿病与肝脏疾病的相互影响

ANALYSIS OFTHE INTERRELATIONSHIP OF DIABETES AND LIVER DISEASE

目的探索糖尿病与肝脏疾病之间的相互影响。方法选择病例对照为研究方式,取70例患有肝脏疾病的患者作为观察组,同时取30例正常人作为对照组,对两组先进行空腹状态下的胰岛素、血糖以及C肽三个指标的检测,之后再进行饭后2 h胰岛素、血糖以及C肽三个指标的检测,并记录数据,对这两种状况的观察结果进行比较。结果慢性肝炎患者的空腹血糖(FBG)水平要比正常人低,且差异具有统计学意义(p<0.05);慢性肝炎及肝硬化患者饭后的胰岛素(P2INS)高于正常人,且具有显著统计学差异(p<0.01);慢性肝炎及肝硬化患者空腹C肽FCP也高于正常人,且具有显著统计学差异(p<0.05);胰岛素抵抗稳态模型评估,慢性肝炎及肝硬化患者高于正常人相比,且具有显著统计学差异(p<0.01)。结论对于患有慢性肝炎疾病的患者,需要对胰岛器官进行功能测定,这样才能够及早发现胰岛素产生的抵抗作用,以便于医护人员进行及时的干预,最终降低糖尿病的发病率,大大改善肝脏疾病患者的健康状况,并且延长他们的寿命。

Objective To explore the relationship between diabetes and liver disease. Methods 100 cases were retrospective analyzed, with 30 physically normal people as control group and 70 patients with liver disease as observation group. The two groups were firstly underwent fasting insulin, blood glucose and C peptide in the detection of three targets, then two hours after a meal blood glucose and insulin, C peptide again. Simultaneously, we made the data record. The data of the two situation were compared. Results The FBG of patients with chronic hepatitis was significantly lower than that of the normal （p 〈 0. 05 ）. The P2INS, FCP and HOMA - IR in cirrhosis patients were all significantly higher than those of the normal（p 〈 0. 05 ）. Conclusion Islet organ function should be tested in patients with chronic hepatitis, so that insulin resistance can be detected early. Furthermore, the medical intervention could be implemented in time, ultimately to reduce the incidence of diabetes, and improve the health status of patients with liver diseases, and extend their lives.