化疗药物对恶性肿瘤患者血糖水平的影响

Relationship between chemotherapy and blood glucose of patients with malignancy

目的了解化疗对恶性肿瘤患者血糖的影响。方法对96例恶性肿瘤患者行含5-氟尿嘧啶、吉西他滨、顺铂、奥沙利铂、奈达铂及表阿霉素等药物方案化疗,化疗中位周期数4个,检测化疗前、中、后的血糖变化。结果化疗后及化疗中血糖相比化疗前均出现明显改变,其中化疗中血糖较化疗前显著升高(t=8.31,P=0.0001),同时化疗后血糖较化疗前也存在显著升高(t=3.87,P=0.0040)。结论化疗可引起恶性肿瘤患者血糖升高。

Objective To investgate the relationship of blood glucose and malignant carcinoma. Methods The change of blood glucose before, during and after chemotherapy in 96 cases with malignancy was detected,these cases received the chemotherapy reagents which included fluorouracil,gemcitabine,cisplatin,oxaliplatin and epidoxorubicina. Results The blood glucose after （t= 3.87, P = 0. 0040） and during （t = 8.31, P = 0. 0001 ） the chemotherapy was higher than the ones before the chemotherapy. Conclusion Chemotherapy can lead to the increasing blood glucose of the patients with malignancy.