脑外伤后C反应蛋白的变化及其临床意义

Changes of C-reactive protein after brain trauma

目的 观察不同程度和不同阶段脑外伤后C反应蛋白（CRP）的变化情况,并探讨其临床意义.方法 选取75例脑外伤患者,按照GCS评分分为轻型组31例、中型组24例和重型组20例.以随机选取的100例同期在本院体检的人员作为正常对照组.在FIA8100免疫定量分析仪上采用胶体金法检测各组患者伤后1、3、7、10天静脉血血清中的CRP含量.结果 与正常对照组比较,脑外伤患者CRP含量在伤后1、3、7、10天均升高（P＜0.05）.轻型组和中型组CRP浓度值在第3天达到最高峰,随后下降至接近正常水平.而重型组CRP浓度值在第3天之后持续升高,在第7天达到最高峰,之后CRP值略微下降并维持较高水平.结论 血清CRP是脑损伤后较敏感且特异的一种标记物,通过对CRP含量的高低变化的观察,可以客观地判断脑外伤患者的严重程度及预后.这对判断病情、治疗效果以及估计预后情况有重要意义.

Objective To observe the changes of C-reactive protein （CRP） after brain trauma and to explore its clinical significance.Methods 75 patients with brain trauma were divided into a mild group（n=31）,a medium group （n=24）,and a severe group （n=20） according to the GCS score.100 cases physically checked at our hospital were selected as a normal control group.Colloidal gold method were used to detect the CRP of all patients in FIA8100 immunoassay analyzer 1,3,7,and 10 days after the trauma.Results The CRP levels increased in patients with brain trauma 1,3,7,10 days after the trauma,which were higher than that in the normal control group （P 〈 0.05）.The CRP reached a peak on day 3 and then decreased to normal level in the mild group and medium group and got to a peak on day 7 and stay on a high level in the severe group.Conclusions Serum CRP is a sensitive and specific indicator for brain trauma.The severity,treatment effect,and prognosis of brain trauma can be evaluated observing the change of CRP.