乌司他丁对食管癌术后早期肺功能的影响

EFFECT OF ULINASTAIN ON EARLY POSTOPERATIVE LUNG FUNCTION OF ESOPHAGEAL CANCER PATIENTS

目的探讨乌司他丁对食管癌术后早期肺功能的影响。方法选择食管癌患者50例,随机分成2组。乌司他丁组(25例),术日及术后7d内每日给予生理盐水250mL+乌司他丁100万U,静脉滴注,2次/d;对照组(25例),术日及术后7d内每日给予生理盐水250mL,静脉滴注,2次/d。比较2组术后2d和8d肺功能指标第1秒用力呼气容积(forced expiratory volume in one second,FEV_1)、一氧化碳的弥散量(diffusing capacity of carbonmonoxide,DLCO)及动脉血氧分压(partial pressure of oxygen,PO_2)的变化。结果 2组术后2d和8d FEV_1、DLCO、PO_2均较术前明显下降,差异有统计学意义(P<0.05);乌司他丁组2d和8d肺功能指标FEV_1、DLCO、PO_2下降幅度均小于对照组,差异有统计学意义(P<0.05);乌司他丁组用药后出现注射部位稍疼痛、发红1例,躯干部位散在皮疹1例,停药后好转。结论乌司他丁能改善食管癌术后早期肺通气功能、弥散功能、肺氧合功能,对患者术后肺功能恢复有积极意义。

Objective To study the effect of ulinastain on early postoperative lung function of esophageal cancer patients. Methods The study selected 50 esophageal carcinoma in-patients who were randomly divided into two groups. Ulinastain group（25 cases）：normal saline 250mL ＋ulinastatin one million unit by intravenous injection,twice a day from the operation day to five days after the operation. The control group（25 cases）：normal saline 250mL by intravenous injection,twice a day,from the operation day to five days after the operation. Comparison was made in postoperative lung function index forced expiratory volume in the first second（ FEV1 ）,diffusion capacity for carbonmonoxide（ DLCO）and partial pressure of oxygen（ PO2 ）of the two groups. Results Postoperative lung function indexes of two groups declined obviously compared with preoperative（ P 〈0. 05 ）;the two groups in comparisons, postoperative lung functions of the ulinastain group index FEV1 ,DLCO,PO2 of ulinastain group were significantly better than these of control group（P〈0. 05）;In ulinastain group,there was a case of pain and red at the the location of injection,and a case of dispersed erythra at the trunk after using ulinastatin, the two patients took a favourable turn after stopping injection. Conclusion Ulinastatin can improve early postoperative pulmonary ventilation function,dispersion function,improve oxygenation index,showing positive significance to recovery of postoperative patients′lung function.