盐酸二甲双胍治疗多囊卵巢综合征对排卵和子宫内膜容受性的影响

Effect on ovulation and endometrial receptivity of metformin hydrochloride in the treatment of polycystic ovary syndrome

目的 分析盐酸二甲双胍治疗多囊卵巢综合征对排卵和子宫内膜容受性的影响。方法对2012年6月~2014年3月来我院就诊的49例多囊卵巢综合征患者进行回顾性分析并将其作为观察组，本组患者均伴有胰岛素抵抗；选取同期来我院就诊的49例多囊卵巢综合征患者作为对照组，本组患者均有自发排卵。观察组口服盐酸二甲双胍治疗，对照组不服用任何药物。比较两组间质、腺体整合素αv、β3的表达及PR、ER、AR表达。结果多囊卵巢综合征患者用药后总排卵率为29.23%，观察组排卵前内膜厚度与对照组比较明显较高，两组有显著性差异（P＜0.05）。观察组间质、腺体整合素αv、β3的表达与对照组比较均明显较高，PR、ER、AR的表达与对照组比较均明显较低，两组有显著性差异（P＜0.05）。结论盐酸二甲双胍治疗多囊卵巢综合征可以提高排卵率，使子宫内膜厚度增加，子宫内膜容受性也得到明显改善。

Objective To analyze effect on ovulation and endometrial receptivity of metformin hydrochloride in the treatment of polycystic ovary syndrome. Methods 49 patients with polycystic ovary syndrome selected from Jun 2012 to Mar 2014 in our hospital were retrospectively analyzed and treated as the observation group , the whole group of patients had insulin resistance. Selected 49 cases of patients with polycystic ovary syndrome in our hospital at the corresponding period and they were treated as the control group, this group of patients had spontaneous ovulation. Observation group was treated with metformin hy-drochloride therapy, the control group took no medication. Compared the interstitial gland integrin αv, β3 expression and PR, ER, AR expression of two groups. Results The total ovulation rate of patients with polycystic ovary syndrome taken medica-tion was 29.23%, the observation group before ovulation, endometrial thickness were significantly higher than those of the con-trol group, there were significant differences between the two groups （P〈0.05）. Interstitial gland integrin αv, β3 expression of observation group were significantly higher than those of the control group, PR, ER, AR expression were significantly lower than those of the control group, there was significant difference in the two groups （P〈0.05）. Conclusion The treatment of polycystic ovary syndrome with metformin hydrochloride can increase ovulation rate , endometrial thickness and improve en-dometrial receptivity.