犬颈动脉囊性动脉瘤模型构建与血流动力学观察

Establishment of Saccular Aneurysms Models of Carotid Arteries in Chinese Rural Dogs

目的探讨犬颈动脉囊性动脉瘤模型的构建,研究颅内动脉瘤发生机制及血管内治疗方法。方法将30只土狗随机分成两组(A、B组),雌性实验犬构成比为50%的A1、A2组和雌性实验犬构成比为33.3%的B1、B2组。将30只成年土狗的颈外静脉嫁接于双侧颈总动脉缺损处,制作颈动脉囊性动脉瘤60枚。术后连续8w DSA检查动脉瘤的大小、造影剂滞留时间和瘤颈宽度等有无变化,分析此模型的稳定性。结果 30只实验犬在双侧颈动脉最终成功制作囊性动脉瘤58枚,成功率为96.7%,平均瘤颈宽度为(5.7±0.7)mm,平均瘤腔直径为(7.9±0.8)mm,术后实验动物均健康成活,无明显神经系统并发症。结论采用犬的双侧颈外静脉节段嫁接于双侧颈总动脉端侧吻合的方式建立犬动脉瘤模型成功率较高,也可方便开展在血管内介入治疗的实验,值得推广。

Objective To establish the models of saccular aneurysms of carotid arteries in Chinese rural dogs, and to explore the pathogenesis and intravascular interventional treatment of intracranial aneurysms （IA）. Methods Thirty healthy Chinese rural dogs were divided into two groups （A and B） randomly,with the ratio of female dogs were 50% and 33.3%respectively. Grafted the external jugular veins （EJV） on the defective tissues of bilateral carotid arteries to construct 60 saccular aneurysms of carotid arteries by surgery. The production rate and size of saccular aneurysms, the accurate resistance time of contrast media, the width of saccular aneurysms＇ necks and hemodynamics were examined by digital subtraction angiography （DSA） consecutively in 8 weeks after operation to verify the stability of saccular aneurysms models of carotid arteries in canine. Results After operations, 30 experimental Chinese rural dogs were healthy and survived without significant neurological complications. Sixty experimental saccular side-wall aneurysms of carotid arteries were created successfully with 58 aneurysms （successful production rate reached 96.7%）. Conclusion Grafted the external jugular veins （EJV） on the defective tissues of bilateral carotid arteries by surgery is an ideal way to construct saccular aneurysms in Chinese rural dogs, which could be performed routine interventional operation by using catheters and worthy of promotion.