子宫内膜异位症患者血清及组织OPN、CA125、HMGB1、VEGF及其受体的变化研究

Study on Serum and Tissue OPN,CA125,HMGB1,VEGF and Its Receptors in Patients with Endometriosis

目的 观察及探究子宫内膜异位症患者血清及组织OPN、CA125、HMGB1、VEGF及其受体的变化状态.方法 选取2011年7月-2013年12月本院收治的75例子宫内膜异位症患者为观察组,并以同期的75例外伤手术患者为对照组,将两组OPN、CA125、HMGB1、VEGF及其受体的血清水平和组织阳性率进行比较,并比较观察组中不同r-AFS分期和分型者的血清水平及组织阳性率.结果 观察组OPN、CA125、HMGB1、VEGF及其受体的血清水平和组织阳性率均高于对照组,且分期较高及存在深部浸润病灶者的血清水平和组织阳性率高于分期较低及未伴有深部浸润病灶者（P＜0.05）,差异有统计学意义.结论 子宫内膜异位症患者血清及组织OPN、CA125、HMGB1、VEGF及其受体均呈现较高状态,且分期及是否存在深部浸润病灶对其有较大影响.

Objective To observe and study the changes of serum and tissue osteopontin（OPN）,carbohydrate antigen 125（CA125）,high-mobility group box 1 protein（HMGB1）, vascular endothelial growth factor（VEGF） and its receptors in patients with endometriosis. Methods Seventy-five patients with endometriosis in our hospital from July 2011 to December 2013 were the observation group,75 patients with trauma operation at the same time were the control group. The serum levels and tissue positive rates of OPN, CA125, HMGB1, VEGF and its receptors of two groups were compared, and positive rates of patients with different stages and types were compared. Results The serum levels and tissue positive rates of OPN, CA125, HMGB1, VEGF and its receptors of observation group were all higher than those of control group, and the serum levels and tissue positive rates in patients with higher stages and deep infiltrative lesions were higher than those of patients with lower stages and without deep infiltrative lesions,all P〈0.05. Conclusion The serum and tissue OPN,CA125,HMGB1,VEGF and its receptors of patients with endometriosis are higher, and the influence of stages and whether or not with deep infiltrative lesions is also significant.