VEGF及FLT-1在结直肠癌中的表达及临床意义

Expression and clinical significance of VEGF and FLT-1 in colorectal carcinoma

目的探讨血管内皮生长因子(VEGF)及其受体FLT-1在直肠癌组织中的表达及其临床病理意义。方法采用免疫组织化学法分别检测82例直肠癌组织中VEGF及其受体FLT-1蛋白的表达,并分析其相关性及临床意义。结果 VEGF在直肠癌组织中阳性表达率为71.9%(59/82),FLT-1在直肠癌组织中的阳性表达率为81.7%(67/82)。VEGF表达与直肠癌淋巴结转移和Duke's分期有关有关(P<0.05)。FLT-1表达与浸润深度和淋巴结转移有关(P<0.05)。VEGF及FLT-1蛋白在直肠癌组织中的表达呈正相关(P<0.05)。结论 VEGF及其受体FLT-1的表达与直肠癌的侵袭和转移有密切关系,值得进一步研究。

Objective To investigate the expression of VEGF and FLT-1 proteins in colorectal carcinoma and analyze their clinicopathological significance. Methods The expression of VEGF and FLT-1 proteins was detected by immunohisto-chemistry in 82 colorectal carcinoma specimens,and the correlation and clinical significance of which were analyzed. Results The positive rates of VEGF protein expression in colorectal carcinoma were 71. 9%（59/82）,and the positive rates of FLT-1 were 81. 7%（67/82）. The expression of VEGF proteins was found to be associated with lymph node metastasis and Dukes stage in colorectal carcinoma（P＆lt;0. 05）,and the expression of FLT-1 was associated with depth of infiltration and lymphnode metastasis（P＆lt;0. 05）. A positive correlation was noted between the expression of VEGF and FLT-1 in colorectal carcinoma （r=0. 565,P＆lt;0. 05）. Conclusion The expression of VEGF and its receptor FLT-1 is closely associated with the invasion and metastasis of colorectal cancer ,which is worthy of further study.