孟鲁司特钠联合布地奈德雾化吸入治疗儿童咳嗽变异性哮喘的临床观察

Clinical Observation of Montelukast Combined with Budesonide Inhalation in Treatment of Children with Cough Variant Asthma

目的观察临床应用孟鲁司特钠联合布地奈德治疗儿童咳嗽变异性哮喘的疗效。方法选取本院2012年7月—2013年2月门诊收治的咳嗽变异性哮喘患儿76例,随机分为对照组43例(布地奈德治疗)和试验组33例(布地奈德联合孟鲁司特钠治疗),比较两组疗效及第一秒末用力呼气容积(FEV1)、最大呼气流量(PEF)、FEV1/用力肺活量(FVC)。结果试验组总有效率(93.94%)高于对照组(90.70%),差异有统计学意义(P<0.05)。治疗后两组FEV1、PEF、FEV1/FVC均较治疗前升高,且试验组高于对照组,差异有统计学意义(P<0.05)。结论临床应用孟鲁司特钠联合布地奈德雾化吸入治疗儿童咳嗽变异性哮喘有很好疗效。

Objective To observe clinical curative effect of montelukast combined with budesonide inhalation in treatment of children with cough variant asthma. Methods 76 cases children with cough variant asthma who were admitted to our hospital outpatient department from July 2012 to February 2013,randomly divided into control group（ treated by budesonide）43 cases,and experimental group（ treated by montelukast combined with budesonide）33 cases. Curative effect and FEV1 ,PEF, FEV1/FVC of two groups were compared. Results Experimental group′s total effective percentage（93. 94%）was higher than control group′s（90. 70%）,the difference was statistically significant（P﹤0. 05）. After treatment FEV1,PEF,FEV1/FVC of two groups increased than before treatment,and experimental group were higher than control group,the differences were sta-tistically significant（ P﹤0. 05）. Conclusion Clinical application of montelukast combined with budesonide inhalation in treatment of children with cough variant asthma has very good curative effect.