摘要
通过对呼吸氮氧混合气模拟缺氧(4800m,3h)的家兔肺表面活性物质变化的研究,我们发现:肺支气管灌洗液中磷脂含量下降59.82%(P<0.05)。肺匀浆中磷脂含量变化,特别是细胞内磷脂呈代偿增加的趋势,稳定性比率随时间的延长而逐渐下降,在15min时,缺氧组与对照组稳定性比率分别为0.88±0.02和0.98±0.01(P<0.05)。缺氧3h,呼吸参数如潮气量,每分钟通气量和食道内压均无显著变化,缺氧组和对照组用以反映P-V关系的A值分别为25.90±3.19和25.16±2.30;B值分别为7.94±1.82和6.56±1.09(P<0.05)。本实验结果说明缺氧(4800m,3h)致肺泡内衬活性物质下降,而在缺氧初期,细胞内磷脂有代偿增加的倾向,这种变化对呼吸功能及肺应变能力无影响。
The surface activity of phospholipids and quantity of it in lung tissue and lung lavage flaid from rabbitts exposed to a simulated altitude of 4 800m(group 1) for 3 hr have been analyzed. Ventilation with nitrogen and oxygen gases mixture containing 10.9% oxygen resulted in a mean decrease of phospholipids of lavage by 59.82% (P<0.05). No significant difference was found between lung tissue of rabbits exposed to hypoxia and the controls (group 2)even though a small increase of cell phspholipids. As a function of time, the bubble stability ratio of both groups, related to surface activity and quantity of pulmonary surfactant, were 0.88±0.02 and 0.98±0.01respectively (P<0.05) at 15 minutes after the starting of photography. The meaurement of respiratory mechanical parameters, A and B, showed no significant variety after 3 hr hypoxia exposure. These changes indicate the decreasing of activity and quantity of pulmonary surfactant after 3 hr exposure to a simulated altitude of 4 800m, hardly have effect on the respiratory function and lung compliance. There is a tendency that the phospholipids in lung cells get increased a little for compensation at the first step of hypoxia.
出处
《中国应用生理学杂志》
CAS
CSCD
1989年第3期289-294,共6页
Chinese Journal of Applied Physiology