电针治疗功能性便秘的临床研究

The Clinical Studie of Electro-acupuncture Stimulation for Functional Constipation

目的观察电针对功能性便秘(functional constipation,FC)患者自主排便次数、大便性状、焦虑抑郁和胃肠蠕动的影响,探讨电针治疗FC的疗效。方法将符合罗马Ⅲ标准的FC患者按21的比例,随机分为电针组和药物组。电针组取双侧曲池、上巨虚穴,治疗4周,前两周每周治疗5次,后两周每周治疗3次;药物组口服枸橼酸莫沙必利,每次5mg,每天3次,连续服药4周。对两组每周自主排便次数、正常性状大便比例、焦虑自评量表(SAS)、抑郁自评量表(SDS)、胃泌素(GAS)、生长抑素(SST)进行评估。结果对比基线期,电针和药物均能增加自主排便次数(P<0.01),改善大便性状(P<0.01);电针组SAS、SDS评分(P<0.01)和血清SST水平(P<0.05)显著下降,血清GAS水平显著上升(P<0.01);药物组SAS、SDS评分和血清SST水平无显著变化,血清GAS水平显著上升(P<0.01)。结论电针治疗可增加FC患者的自主排便次数,改善大便性状,降低焦虑和抑郁状况及血清SST水平,提高血清GAS水平,从而有效治疗FC。

Objective To observe the impact of electro-acupuncture（EA）stimulation on stool frequency,stool consistency,anxiety and depression, and gastrointestinal motility in patients with functional constipation（FC）, and to explore the therapeutic effects of EA for FC. Methods FC patients who meet Rome Ⅲ criteria were randomly assigned to EA group and medicine group in 2 ： 1 ratio. In EA group, patients were treated with EA at Quchi （LIll）and Shangjuxu（ST37）bilaterally for 4 weeks,5 times a week in the first 2 weeks and 3 times a week in the last 2 weeks. In medicine group, 5 mg mosapride citrate was administered orally 3 times a day for 4 weeks. Stool frequency, stool consistency, self-rating anxiety scale（SAS）, self-rating depression scale（SDS）, serum levels of gastrin（GAS）and somatostatin（SST）were evaluated. Results Compared with the baseline,stool frequency per week and the percentage of normal stools per week were both improved significantly in two groups（P〈0.01）. In EA group, the scores of SAS and SDS（P〈0.01）and the serum level of SST（P〈0.05）decreased significantly, the serum level of GAS increased significantly（P〈0.01）. In medicine group, the scores of SAS and SDS and the serum level of SST did not change significantly, while the serum level of GAS increased significantly （P 〈 0.01） . Conclusion EA therapy can increase stool frequency,improve stool consistency, decrease the patient 〈s anxiety and depression and the serum level of SST,and increase the serum level of GAS effectively. EA treatment is effective for FC patients.