左炔诺孕酮宫内缓释系统在子宫腺肌病治疗中的临床价值

The clinical application of levonorgestrel-releasing intrauterine system on the treatment of clinical analysis of adenomyosis

目的：探讨左诀诺孕酮宫内缓释系统在子宫腺肌病治疗中的临床应用价值。方法选取2010年3月至2013年3月于我院诊断为子宫腺肌病患者134例，应用随机数字表分为对照组67例和观察组67例，对照组患者给予孕三烯酮口服治疗，观察组患者行左炔诺孕酮宫内缓释系统放置治疗，观察两组患者治疗前后疼痛评分、月经量、子宫体积、子宫内膜厚度的变化情况，并对两组患者治疗前、后各指标变化进行统计学对比分析。结果治疗后观察组患者疼痛评分为（1.85±0.57）分，月经量（45.37±11.94）ml，子宫体积（129.47±8.67）mm^3，子宫内膜厚度（4.02±2.04）mm，均明显低于对照组[（4.82±2.07）分、（61.47±12.07）ml、（148.54±12.47）mm^3、（6.35±2.64）mm]，组间比较差异均有统计学意义（t 值分别为5.397、6.047、5.334、4.681，P 均＜0.05）。结论左炔诺孕酮宫内缓释系统治疗子宫腺肌病安全、有效，值得推广。

Objective To investigate the clinical effect of left tactic norgestrel releasing intrauterine system in the treatment of adenomyosis. Methods One hundred and thirty-four patients with diagnosis of uterine adenomyosis were selected as our subjects in Xuanwu Hospital of Capital Medical University from Mar. 2010 to Mar. 2013. They were randomly divided into control group（67 cases）and observation group（67 cases）. Patients in control group were give Gestrinone with oral,and in observation group were give left acetylene connaught progesterone intrauterine placed treatment slow-release system. The information of pain scores,menstruation, uterine volume,endometrial thickness were recorded. Results After treatment,pain score,menstrual quantity, uterine volume and endometrial thickness in observation group were（1. 85 ± 0. 57）,（45. 37 ± 11. 94）ml, （129. 47 ± 8. 67）mm^3 ,（4. 02 ± 2. 04）mm,significantly lower than the control group（（4. 82 ± 2. 07）,（61. 47 ± 12. 07）ml,（148. 54 ± 12. 47）mm^3 ,（6. 35 ± 2. 64）mm）,and the differences between groups were statistically significant（t = 5. 397,6. 047,5. 334,4. 681 respectively;P 〈 0. 05）. Conclusion The therapy of levonorgestrel releasing intrauterine system on treating adenomyosis of uterus is safe and effective. It is worthy of promotion.