探究坤泰胶囊联用雌激素替代疗法治疗围绝经期综合征临床疗效

Clinical Efficacy of Kuntai Capsule and Estrogen Replacement Therapy on Perimenopausal Syndrome

目的:探究坤泰胶囊联用雌激素替代疗法治疗围绝经期综合征临床疗效。方法:110例患者按照随机数字表法分为治疗组与对照组。每组各43例。对照组接受戊酸雌二醇2mg,每天1次,治疗1个月。治疗组接受戊酸雌二醇1mg,每天1次,治疗1个月。治疗组患者给予坤泰胶囊,每天3次,每次4粒,治疗1个月。结果:对照组中显效有22例,有效有13例,总有效率为63.6%。治疗组的显效例数为28,有效有18例,总有效率83.6%。治疗组的总有效率优于对照组,差异明显,具有统计学意义(χ2=5.67,P<0.05)。相比治疗前,治疗后对照组和治疗组血清FSH、LH、E2显著性差异,具有统计学意义(P<0.05)。相比对照组,治疗组中FSH和E2变化幅度优于对照组的变化,具有统计学意义(t=1.25,2.44,P<0.05)。结论:坤泰胶囊联用雌激素替代疗法治疗围绝经期综合症临床疗效显著,不良反应少。

Objective：To explore the clinical efficacy of Kuntai capsule and estrogen replacement therapy on perimenopa-usal syndrome .Methods：110 patients were randomly divided into treatment group and control group .There were 43 ca-ses in each group .The control group was received 2 mg estradiol valerate one time a day .The treatment group received 1 mg estradiol valerate one time a day .The treatment of Livial lasted for a month .The patients in treatment group were also given Kuntai capsules three times a day for one month .Results：In the control group 22 cases were markedly effec-tive .13 cases had effect .The total effective rate was 63 .6%.In the treatment group 28 were markedly effective .18 ca-ses had effect .The effective rate was 83 .6%.The total efficiency in the treatment group was better than that in the con-trol group.The differences had a statistical significance （χ^2 =5.67,P〈0.05）.Compared with those before treatment, serum FSH , LH, E2 of control group and treatment group had a significant difference （ P〈0 .05 ） .Compared with the control group , the changes of FSH and E 2 in the treatment group were better than those in the control group , which had a statistical significance （t=1.25, 2.44,P〈0.05）.Conclusion：Kuntai capsule and estrogen replacement therapy on perimenopausal syndrome with estrogen replacement show a better clinical efficacy and fewer adverse reactions .