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内源性大麻素与癫痫的研究进展 被引量:1

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摘要 癫痫( epilepsy )是一种以脑神经元异常放电引起的慢性反复发作性短暂脑功能失调综合征。目前很多药物虽能缓解癫痫症状,却不能有效抑制病情恶化。尤其是癫痫持续状态( status epilepticus ,SE),因此,确定药物靶点治疗以减轻癫痫的病理过程显得尤为重要。研究表明,大麻及其衍生物自古以来就被用于癫痫发作的治疗,而内源性大麻素参与调制癫痫活动的终止。本文拟综述内源性大麻素与癫痫之间的关系及其研究进展。
作者 贺锐 杨红卫
出处 《广东医学》 CAS CSCD 北大核心 2014年第12期1961-1963,共3页 Guangdong Medical Journal
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  • 1Fredholm BB,Chen JF,Cunha RA,et al.Adenosine and brain func-tion[J].Int Rev Neurobiol,2005,63:191-270.
  • 2Boison D,Chen JF,Fredholm BB.Adenosine signalling and functionin glial cells[J].Cell Death Differ,2010,17(7):1071-1082.
  • 3Pascual O,Haydon PG,Casper KB,et al.Astrocytic purinergic sig-naling coordinates synaptic networks[J].Science,2005,310:113-116.
  • 4Boison D.The adenosine kinase hypothesis of epileptogenesis[J].Prog Neurobiol,2008,84(3):249-262.
  • 5Studer FE,Fedele DE,Boison D,et al.Shift of adenosine kinase ex-pression from neurons to astrocytes during postnatal development sug-gests dual functionality of the enzyme[J].Neuroscience,2006,142:125-137.
  • 6Boison D.Adenosine dysfunction and adenosine kinase in epileptogen-esis[J].Open Neurosci J,2010,4:93-101.
  • 7Theofilas P,Boison D,Brar S,et al.Adenosine kinase as a target fortherapeutic antisense strategies in epilepsy[J].Epilepsia,2011,52(3):589-601.
  • 8Etherington LA,Patterson GE,Meechan L,et al.Astrocytic adeno-sine kinase regulates basal synaptic adenosine levels and seizure activi-ty but not activity-dependent adenosine release in the hippocampus[J].Neuropharmacology,2009,56(2):429-437.
  • 9Seifert G,Carmignoto G,Steinhuser C.Astrocyte dysfunction in ep-ilepsy[J].Brain Research Reviews,2010,63(1-2):212-221.
  • 10Shachnai L,Shimamoto K,Kanner BI.Sulfhydryl modification ofcysteine mutants of a neuronal glutamate transporter reveals an inverserelationship between sodium dependent conformational changes andthe glutamate-gated anion conductance[J].Neuropharmacology,2005,49(6):862-871.

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