摘要
目的:观察氟伐他汀、贝那普利单用及联用对稳定型心绞痛血浆同型半胱氨酸(HCY)的影响。方法:选择医院门诊及住院稳定型心绞痛血浆HCY>15μmol/L的患者120例,随机分为4组,常规治疗组:阿司匹林+硝酸酯类药;氟伐他汀组:氟伐他汀(40mg,1次/d)+常规治疗;贝那普利组:贝那普利(10mg,1次/d)+常规治疗;联合治疗组:氟伐他汀(40mg,1次/d)+贝那普利(10mg,1次/d)+常规治疗。治疗3月后再次测定检测HCY。结果:①常规治疗组治疗前后血浆HCY差异无统计学意义(P>0.05);氟伐他汀组、贝那普利组、联合治疗组治疗后血浆HCY水平明显降低,差异具有统计学意义(P<0.01);②治疗后,氟伐他汀组与贝那普利组血浆HCY比较,差异无统计学意义(P>0.05),但联合治疗组与氟伐他汀组、贝那普利组比较差异有统计学意义(P<0.01)。结论:氟伐他汀和贝那普利具有协同作用,两者都有降低稳定型心绞痛患者血浆中HCY水平的效能。
Objective: To observe impacts of Fluvastatin and Benazepril used seperately or combination on plasma homocysteine( HCY) of stable angina pectoris. Methods: 120 cases of inpatients and outpatients of stable angina pectoris with HCY >15μmol /L in the Second People's Hospital of Jiangmen City were randomly divided into four groups: Aspirin + nitrates drugs for the conventional treatment group; Fluvastatin( 40 mg,1times /day) plus conventional therapy for the Fluvastatin group;Benazepril( 10 mg,1 times /day) plus conventional therapy for the Benazepril group; Fluvastatin( 40 mg,1 times /day) +benazepril( 10 mg,1 times /day) plus conventional therapy for the combination therapy group. Determination of the HCY was detected again 3 months later. Results: ①In the conventional treatment group determination of plasma HCY showed no significant difference( P > 0. 05) before and after treatment; plasma HCY levels decreased significantly in the Fluvastatin group,the Benazepril group and the combination therapy group. There was a statistically significant difference( P < 0. 01); ②the difference was not statistically significant( P > 0. 05) between the Fluvastatin group and the Benazepril group after treatment,but there was a statistically significant difference between the combination therapy group and the Fluvastatin group,the Benazepril group( P < 0. 01). Conclusion: Fluvastatin and Benazepril can be combined to achieve a synergistic effect on reducing plasma HCY levels of the patients with stable angina pectoris.
基金
江门市科技局立项课题(江科【2011】94号)
